Phase 3 Rheumatoid Arthritis Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who were diagnosed with rheumatoid arthritis (RA) at least 6 months ago but no more than 15 years ago, based on recognised medical criteria.
• People who still have moderate to severe RA symptoms despite taking methotrexate (MTX), meaning they have 6 or more swollen joints and 6 or more tender joints, plus elevated inflammation markers in their blood and a positive RA-related blood test result.
• People who have been taking a stable dose of methotrexate (between 10 and 25 mg per week) for at least 12 weeks, with no dose changes in the 8 weeks before joining the trial.
• People who have been on a stable dose of anti-inflammatory or pain relief medications for at least 4 weeks before joining the trial, if these medications are being used.
• People who have been taking a stable low dose of steroid medication (no more than 10 mg of prednisone or equivalent per day) for at least 4 weeks before joining the trial, if steroids are being used.
• People who are considered generally medically stable, as assessed by the treating doctor.
• People who agree to use highly effective contraception for up to 6 months after the last dose of the study drug.

Who may not be able to join:

• People who have previously been treated with a biologic or targeted synthetic disease-modifying medication (a specific class of RA treatments).
• People who have previously been treated with a monoclonal antibody medication for any condition other than RA.
• People who have a known allergy or sensitivity to any ingredient in the study drug or the prefilled syringe used to deliver it.
• People whose arthritis began before the age of 16, or who currently have a different type of inflammatory joint disease other than RA.
• People who have serious body-wide complications from RA, beyond rheumatoid nodules or a secondary dry eye/dry mouth condition (secondary Sjögren's syndrome).
• People with an active infection or infections that could return and cause serious illness. (Note: people found to have latent tuberculosis during screening may be able to be re-screened after starting an approved treatment — confirm with trial site.)
• People who have had a solid organ or blood cancer within the past 5 years.
• People who are currently pregnant or breastfeeding.
• People who have any other medical condition that the treating doctor believes could affect their safety, their ability to participate, or the reliability of the trial results.

Important: Always verify eligibility with the trial site directly before applying.