Early Phase 1 Rheumatoid Arthritis Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- You are willing to take part, can follow all the study steps, and have signed a consent form agreeing to participate.
- You have been diagnosed with Rheumatoid Arthritis (RA) for at least 3 months, your RA is moderately to severely active, and previous treatments (such as disease-modifying or biologic drugs) have not worked well enough, stopped working, or caused side effects you couldn't tolerate.
- You have been diagnosed with Antisynthetase Syndrome (ASyS) for at least 3 months and your condition is moderately to severely active (confirm with trial site).
- You are between 18 and 70 years old (male or female).
- Your doctors estimate you are expected to live for more than 12 weeks.
- Your kidney function and liver enzyme levels (AST and ALT) are within acceptable ranges as measured by blood tests.
- You have a general health/activity level score of 0–2 on a standard medical scale (meaning you are able to care for yourself and are not fully bedridden) (confirm with trial site).
- An ultrasound of your heart shows it is working reasonably normally, with a pumping efficiency of at least 45%.
- It has been at least 2 weeks since your last dose of hormonal, immune-suppressing, or other experimental treatment.
Who may not be able to join:
- You have had a severe allergic reaction to, or cannot take, any of the trial medications: cyclophosphamide, fludarabine, or tozumab.
- You have a genetic condition affecting your bone marrow, such as Fanconi syndrome, Kostmann syndrome, or Shwachman syndrome.
- You currently have a serious active infection (bacterial, viral, or fungal) that requires strong intravenous antibiotics or is not under control.
- You have been diagnosed with severe (Grade III or IV) heart failure.
- You have a history of epilepsy or other serious brain or nervous system conditions.
- You have had cancer in the past, unless it was a skin cancer or cervical cancer that has been fully cured, or a tumour that is no longer active (confirm with trial site).
- You have significant bleeding problems, such as gastrointestinal bleeding or blood clotting disorders.
- You have had unstable chest pain (angina), significant heart failure symptoms, or a heart attack in the last 6 months.
- You are currently pregnant, breastfeeding, or planning to become pregnant within six months.
- You have taken part in another clinical trial and received treatment within the last 3 months.
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Phone: 086 18061202878
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Incidence of Dose-Limiting Toxicity (DLT); Incidence of Treatment Emergent Adverse Events (TEAEs)
Can't join this trial?
Data last synced from ClinicalTrials.gov: 21 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.