Heart Disease Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- People (male or female) who have a severe form of cardiogenic shock (when the heart cannot pump enough blood) that has not responded to standard treatment, and who need a temporary machine to support their heart — either a device called VA-ECMO or a small pump device called an Impella® CP
- People (male or female) who have cardiogenic shock but do not need, or are not suitable for, a temporary heart support machine such as ECMO, Impella®, or an intra-aortic balloon pump (this group would be in the comparison/control group of the trial)
- People aged over 18 years old
- People who understand French
- People who are able to give consent, or whose legal representative or close relatives can give consent on their behalf (since patients may be sedated and on a breathing machine at the time of enrolment). Full consent from the patient themselves would be sought later, at the time of a second blood sample after the heart support machine is removed, if the patient recovers
Who may not be able to join:
- People who have a severe lung condition called ARDS that is not responding to treatment and who need a type of lung support machine called VV-ECMO
- People who are unable to receive a specific medication mixture (called the "Geneva Cocktail") through a feeding tube into the stomach or gut
- People with severely reduced kidney function, as measured by a specific calculation (confirm with trial site)
- People with severe long-term liver disease, classified as a certain level of severity (confirm with trial site)
- People who have a known sensitivity or allergic reaction to any of the drugs used in the Geneva Cocktail
- People who are currently taking medications that are known to strongly interfere with the way the body processes certain drugs, specifically medications that strongly affect liver enzymes called CYPs (confirm with trial site for the specific list of medications)
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Phone: +41795530888
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
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Trial details
Where this trial is recruiting
Primary endpoints
Evaluate the impact of temporary mechanical circulatory support on the activity of CYPs as measured with metabolic ratios MRs (CYP activity at D3 post tMCS implantation and 14 days after tMCS explantation vs the activity of CYPs in the control grou
Can't join this trial?
Data last synced from ClinicalTrials.gov: 21 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.