Phase 2 Liver Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are willing to take part and have signed a consent form agreeing to join the study
• People aged 18 or older at the time of signing the consent form
• People who have been diagnosed with hepatocellular carcinoma (a type of liver cancer) through clinical assessment or a tissue biopsy
• People whose liver cancer is at an advanced stage (Barcelona Clinic Liver Cancer stage C), meaning it has spread into nearby blood vessels or bile ducts, or to distant parts of the body — but not including a specific severe type of blood vessel involvement called Vp4-type tumor thrombus (confirm with trial site)
• People who have not yet received any systemic (whole-body) treatment for their liver cancer, or who have had local treatments such as surgery, ablation, radiation, or TACE but still have remaining or progressing disease, with at least one month having passed since the last local treatment
• People with a general health score of 0 or 1 on a standard scale (meaning fully active or able to carry out light activity), and whose liver function falls within a certain acceptable range on a standard grading system
• People with no history of autoimmune disease (conditions where the immune system attacks the body's own tissues)
• People whose doctors expect them to live for at least three more months
• People who have at least one tumour that can be measured on a scan, meeting specific size requirements
• People whose blood, liver, and kidney test results from within the past week fall within the ranges required by the trial, including acceptable levels of blood cell counts, liver enzymes, kidney function markers, and clotting measures
• Women who could become pregnant must have a negative pregnancy test within seven days before joining, must not be breastfeeding, and must agree to use contraception during the study and for six months after; men must also agree to use contraception during the study and for six months after

Who may not be able to join:

• People with a severe allergy to iodine-based contrast dyes that would prevent them from receiving a type of chemotherapy delivered directly into the liver's blood supply
• People who have taken immune-suppressing medications or high-dose steroid medicines within the past month
• People with active infections that cannot be adequately controlled
• People with serious swollen veins in the oesophagus or stomach that are untreated or incompletely treated, especially if there is bleeding or a high risk of bleeding
• People who have cancer that has spread to the brain or bones and requires urgent surgery or radiation treatment
• People who are pregnant, suspected to be pregnant, or currently breastfeeding
• People currently taking or who have recently taken (within 10 days before the study starts) high-dose aspirin or certain blood-thinning medications such as clopidogrel, dipyridamole, ticlopidine, or cilostazol
• People who have had a stroke, mini-stroke, brain bleed, or a blood clot in the lungs within the past six months
• People with a condition affecting the immune system, whether present from birth or developed later in life
• People with a history of any other type of cancer
• People who have had a heart attack, severe chest pain, or heart failure within the past 12 months
• People whose kidneys are not working well enough and who require dialysis
• People who have had an organ transplant
• People with serious physical or mental health conditions, or significant abnormal test results, that may make participation unsafe or affect the study results

Important: Always verify eligibility with the trial site directly before applying.