Phase 2 Liver Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are 18 years of age or older.
• You have been diagnosed with liver cancer (hepatocellular carcinoma, or HCC) confirmed by imaging, biopsy, or cell testing, and your cancer is at an advanced stage or a stage where curative or local treatments are not suitable.
• You have never received systemic (whole-body) treatment for your liver cancer.
• You have at least one area of cancer that can be measured on a CT scan or MRI.
• Your liver is functioning at an acceptable level, as measured by a scoring system called Child-Pugh (scores 5–7), and your general health and ability to carry out daily activities meets a certain standard (confirm with trial site).
• If you have chronic hepatitis B, your virus levels must be very low (below 100 IU/mL) and you must already be on antiviral medication.
• Your blood counts, liver enzyme levels, and kidney function are within acceptable ranges as tested by blood tests (confirm with trial site for specific values).
• You are expected to live for at least 12 weeks.
• If you are a woman who could become pregnant, you must have a negative pregnancy test within 7 days before starting the trial.
• You are willing and able to follow all the trial requirements, including attending scheduled visits and using contraception if required.
• You have signed a form giving your informed consent to take part.

Who may not be able to join:

• You are on a waiting list for a liver transplant or have very advanced liver disease.
• You have a significant history of heart disease or have had serious gastrointestinal (digestive tract) bleeding within the past 4 weeks.
• You have had a blood clot or stroke (including mini-strokes) in the past 6 months, such as a clot in a deep vein or in the lungs.
• You have previously had any systemic cancer treatment, hormone-based cancer treatment, or immunotherapy.
• You have previously been treated with a specific type of liver-directed chemotherapy called HAIC.
• You have had radiotherapy within the last 4 weeks before the trial starts.
• You have had major surgery within the last 4 weeks, or you have not yet fully recovered from major surgery.
• You have or have had a second type of cancer, unless it was a common skin cancer or very early-stage cervical cancer that has been fully treated.
• You have a weakened immune system, for example if you are HIV positive.
• You have taken part in another clinical trial or received an experimental treatment within the past 30 days (or longer, depending on the previous treatment — confirm with trial site).
• You have already participated in this specific trial before.
• You have certain other medical conditions, including but not limited to: a history of lung scarring (interstitial lung disease); both hepatitis B and hepatitis C infections at the same time; pancreatitis; active tuberculosis; any active infection requiring treatment; a history of organ or tissue transplant; an immune deficiency condition or use of steroid or immune-suppressing medication recently; an active or severe autoimmune disease requiring treatment in the last 3 months (some autoimmune conditions may be exceptions — confirm with trial site); received a live vaccine in the last 30 days; or cancer that has spread to the brain (some exceptions may apply — confirm with trial site).
• You are currently taking any medication known to interfere with the drugs used in this trial.
• You are receiving any other cancer treatment not specified by this trial.
• You have received another experimental drug within the past 28 days.
• You have previously been treated with certain types of immunotherapy drugs that target specific immune system proteins (such as anti-PD-1, anti-PD-L1, anti-CTLA-4, or similar treatments — confirm with trial site).
• You are pregnant, breastfeeding, or unwilling or unable to use a reliable method of contraception during the trial (acceptable methods include implants, injections, combined oral contraceptives, hormonal intrauterine devices, full abstinence, or a vasectomised partner).
• You have a significant history of not following medical treatment plans, or you are unable to give reliable informed consent.

Important: Always verify eligibility with the trial site directly before applying.