Phase 2 Liver Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are 18 years old or older
• You are generally in good health and able to carry out daily activities with little or no limitation (confirm with trial site)
• Imaging scans show a liver cancer (specifically intrahepatic cholangiocarcinoma) that can be surgically removed — a tissue biopsy is not required before surgery
• You are healthy enough to have open abdominal surgery
• Based on a specific type of CT scan, it is possible for surgeons to place a small tube (catheter) into an artery near your liver to deliver chemotherapy directly (confirm with trial site)
• Your blood counts, liver function, and kidney function are within acceptable levels, tested within the last 30 days
• You have enough healthy white blood cells, infection-fighting cells (neutrophils), and platelets in your blood
• Your kidneys are filtering blood at an acceptable rate
• Your haemoglobin (the part of blood that carries oxygen) is at an acceptable level
• Your bilirubin level (a measure of liver function) is not too high
• You are willing and able to give written consent to take part in the trial

Who may not be able to join:

• The cancer has spread to areas outside the liver at the time of first diagnosis (though patients with very small, uncharacterised lesions of 1 cm or less, or nearby lymph node involvement, may still be eligible — confirm with trial site)
• You have had another type of cancer, unless it was a common skin cancer, or a previous cancer that was fully treated at least 3 years ago with no signs of return, or one where life expectancy is greater than 5 years
• You have a known inherited condition that affects how your body breaks down certain chemotherapy drugs (called DPYD deficiency — homozygous type)
• You have previously had radiation therapy, tumour burning/freezing (ablation), or surgery to remove part of your liver for this type of cancer
• You have signs of high blood pressure in the liver's blood supply system, such as fluid build-up in the abdomen, swollen veins in the food pipe or stomach, or a blood clot in the main liver vein (some fluid after surgery may be acceptable — confirm with trial site)
• There is a blood clot in the portal vein of the part of the liver that would remain after surgery
• You are pregnant or currently breastfeeding
• You have a significant mental health condition that, in the doctor's judgement, would prevent you from giving informed consent or following the treatment plan
• You have other serious health conditions that could put you at risk or prevent you from completing the study
• You have received a transplanted organ and need medication to prevent rejection
• You have a serious infection that is not under control or is currently being treated
• You are already taking part in another interventional clinical trial for this type of liver cancer that measures survival as an outcome
• You are already taking part in another clinical study involving an investigational medical treatment
• There are personal, psychological, family, social, or location-related circumstances that might make it difficult to follow the study plan and attend follow-up appointments (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.