Phase 3 Heart Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been admitted to hospital with heart failure for more than 24 hours, with new or worsening symptoms and signs confirmed by physical examination, lab results, or monitoring, and who are receiving or planned to receive heart failure treatment.
• People who are at least 10 pounds (4.5 kg) above their normal stable body weight, as estimated by their healthcare provider.
• People who are currently taking a daily water pill (loop diuretic) prescribed before this hospital stay.
• People aged 22 or older who are able to give informed consent and follow the study procedures.
• People who show at least one sign that their body may not be responding well to water pills, such as low chloride levels in the blood, producing less than 1 litre of urine in the 6 hours after receiving a water pill through a drip, or having low sodium levels in their urine 1–2 hours after receiving a water pill through a drip.

Who may not be able to join:

• People with urinary or bladder problems that would make inserting a urinary catheter unsafe or not possible.
• People with unstable blood pressure or circulation, including those whose blood pressure dropped very low in the past 48 hours, who needed blood pressure-supporting medications through a drip in the past 48 hours, or who used a mechanical heart support device in the past week.
• People who have had a very fast, uncontrolled heart rate (above 130 beats per minute for more than 10 minutes) in the past 48 hours.
• People with severe lung disease who need more than 2 litres per minute of oxygen at home on an ongoing basis.
• People with an active infection that has spread through the body, such as one causing a fever or an elevated white blood cell count.
• People with significantly reduced kidney function below a certain threshold, or who are currently on dialysis or another kidney replacement treatment.
• People with certain serious heart structural conditions — such as severe valve narrowing, complex congenital heart disease, or certain types of stiff or thickened heart muscle disease — where aggressive fluid removal would be considered unsafe (confirm with trial site).
• People who have had a heart attack, heart bypass surgery, or stroke within the past 30 days. Note: a small rise in a heart enzyme alone (troponin) is not a reason to be excluded.
• People with severely abnormal blood electrolyte levels (such as very low potassium, magnesium, or sodium) at the time of screening. People whose levels are corrected after screening cannot be re-tested for this criterion.
• People with another serious illness or condition that the trial team believes would make it difficult to follow the study procedures or attend follow-up visits, including those expected to stay in hospital for reasons unrelated to fluid removal treatment.
• People who are currently taking part in another interventional clinical trial.
• People with a life expectancy of less than 6 months.
• People who are pregnant or breastfeeding.

Important: Always verify eligibility with the trial site directly before applying.