Phase 4 Rheumatoid Arthritis Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have never previously been treated with methotrexate (MTX), by any method of taking it
• People who are 18 years of age or older at the time of signing the consent form
• People who have been diagnosed with rheumatoid arthritis according to the 2010 EULAR/ACR classification criteria
• People whose rheumatoid arthritis is measured as moderately to highly active (an SDAI score above 11) at the screening stage
• People who have never been treated with JAK inhibitors or biological disease-modifying drugs (bDMARDs) (confirm with trial site if unsure which medications these include)
• Women of childbearing potential who are able to use appropriate contraception during the study and for at least one menstrual period after finishing MTX treatment
• Women who have been through menopause for at least one year before signing the consent form, or who are unable to have children due to sterilisation
• Men who are able to father children and who can use appropriate contraception during the study and for at least three months after finishing MTX treatment
• People who are able to understand the study procedures and are willing to provide written consent to participate

Who may not be able to join:

• Women who are pregnant or who may be pregnant
• People who have had an allergic reaction to any ingredient in the study drug
• People with a history of certain serious blood or lymphatic conditions, such as myelodysplastic syndrome, aplastic anaemia, or erythroblastoma
• People who have been diagnosed with or treated for a lymphoproliferative (lymph system) disease within the past five years
• People with significantly low white blood cell counts or platelet counts, as measured by specific blood test thresholds
• People with serious liver problems, including active hepatitis B or C, cirrhosis, or significantly elevated liver enzyme levels (AST or ALT above 150 U/L)
• People with severe kidney problems, including those on dialysis or with a kidney filtration rate (GFR) below 30 mL/min/1.73m²
• People who have fluid build-up around the lungs (pleural effusion) or in the abdomen (ascites)
• People with active tuberculosis
• People whom the principal investigator considers medically unsuitable to participate for any other reason

Important: Always verify eligibility with the trial site directly before applying.