Alzheimer's Disease Trial, By Invitation
voxsanity.com.au · Eligibility summary from public government registries · 18 August 2026 · not medical advice
Who may and may not be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who may be able to join
- People aged between 50 and 80 years old.
- People who have been diagnosed with Alzheimer's disease according to the 2024 diagnostic guidelines published by the National Institute on Aging and Alzheimer's Association (NIA-AA).
- People with moderate-to-severe memory and thinking problems, as measured by two standard assessment tools (CDR score of 2 or higher, and MMSE score below 20).
- People who have been on a stable medication routine for at least one month, with no planned medication changes within three months of joining the trial.
- People (and their families) who have been fully informed about the trial's purpose, expected effects, and potential risks, and who agree to take part voluntarily by providing biological samples and signing a consent form.
Who may not be able to join
Each point below is a reason the trial team may not be able to accept someone. It is not a list of requirements to meet.
- People whose dementia is caused by something other than Alzheimer's disease — for example, vascular dementia, brain infections (such as HIV or syphilis), Creutzfeldt-Jakob disease, Huntington's disease, Parkinson's disease, Lewy body dementia, brain injury, drug or alcohol-related brain damage, carbon monoxide poisoning, liver or lung disease affecting the brain, brain tumours or blood clots on the brain, thyroid or parathyroid conditions, vitamin deficiencies, or any other known cause of dementia.
- People with serious or unstable health conditions affecting the heart, liver, kidneys, digestive system, lungs, hormones, nervous system (apart from Alzheimer's), immune system, or blood — or any other condition the trial doctor believes could affect the study results — or people with a life expectancy of less than 24 months.
- People who have had a cancer diagnosis within the past 5 years, with some exceptions such as certain slow-growing or non-spreading skin cancers, cervical carcinoma in situ, non-progressive prostate cancer, or other cancers considered low-risk for return or spread.
- People who currently have a primary psychiatric condition (other than Alzheimer's-related cognitive impairment) that, in the trial doctor's opinion, could interfere with the study assessments or results — and people with a history of schizophrenia or other long-term psychiatric illness are required to be excluded.
- People who, in the trial doctor's judgement, are considered to be at significant risk of suicide.
- People who are unable to read or who do not have enough education to complete the study's assessment questionnaires.
- People who have had a history of alcohol or drug misuse (not including smoking) in the two years before the screening visit.
- People with a significant history of multiple or severe drug allergies, serious sensitivity conditions, or severe reactions to treatments (such as certain serious skin reactions).
- People who have clinically significant abnormal results on physical or neurological examination, vital signs, heart trace (ECG), or laboratory tests at screening that the trial doctor considers harmful, disruptive to the study, or possibly pointing to another cause of dementia.
- People whose MRI scan at screening shows significant abnormalities that suggest another possible cause of progressive memory and thinking problems, or findings that could make participation unsafe — for example, more than two areas of brain damage larger than 2 cm, damage in certain key brain regions, or a high score on a scale measuring damage to the brain's white matter (Fazekas Scale grade above 2).
- People for whom an MRI scan is not safe or possible — for example, due to claustrophobia or the presence of certain metal implants or a pacemaker.
- People for whom the trial's surgical procedure (LVA surgery) would be unsafe — for example, due to serious infection at the surgical site, or severe heart, lung, liver, kidney, or other organ problems that would prevent safe use of general anaesthesia.
- People who are currently taking part in another interventional clinical trial, or in any other medical research considered incompatible with this study.
- People for whom completing the study is not practical — for example, people who do not have a consistent caregiver.
- People who are pregnant or planning to become pregnant.
- People with a Global Deterioration Scale (GDS) score of 7, as the level of decline at this stage makes it not possible to follow the study's procedures or reliably participate in assessments after surgery.
- People who are staff members of the research centre running this study, or their immediate family members (defined as a spouse, parent, child, or sibling, whether biological or adopted).
- People who are currently receiving, or have previously received, treatments targeting amyloid beta as a disease-modifying therapy for Alzheimer's disease, or who have previously participated in a clinical trial involving such treatments.
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
If you need support right now
This page includes language about suicide and self-harm, because that is how the trial's eligibility criteria are written. If reading it has been hard, you do not have to keep going. The services below are free, confidential, and answered by people trained for exactly this.
If you or someone else is in immediate danger, call 000.
- Lifeline — 24/7 crisis support: 13 11 14
- Suicide Call Back Service — 24/7 counselling: 1300 659 467
- 13YARN — 24/7, for Aboriginal and Torres Strait Islander people: 13 92 76
- Beyond Blue — 24/7 mental health support: 1300 22 4636
- Kids Helpline — 24/7, free and private for anyone aged 5 to 25: 1800 55 1800
- headspace — mental health support for 12 to 25 year olds: headspace.org.au
- Emergency: 000
Outside Australia? The numbers above are Australian and will not work from overseas. Find a Helpline is a free directory of crisis lines in over 130 countries, run by ThroughLine with the International Association for Suicide Prevention. If you are in immediate danger, call your local emergency number.
Voxsanity is not a crisis service, and nothing on this page is medical advice. More Australian services are listed on our support lines page.
If this is close to home
This page includes language about advanced illness, prognosis, or palliative care, because that is how the trial's eligibility criteria are written. Seeing it set out plainly can land hard, whether it is about you or about someone you are caring for. You do not have to be at a crisis point to talk to someone.
- Griefline — grief and loss counselling, 9am to 6pm weekdays and midday to 6pm weekends (AEST/AEDT): 1300 845 745
- Carer Gateway — practical and emotional support if you are caring for someone, 8am to 5pm weekdays: 1800 422 737
- Canteen — for 12 to 25 year olds affected by cancer, their own or a family member's: 1800 945 215
- Palliative Care Australia — directory of palliative care services near you: palliativecare.org.au
- Lifeline — 24/7, for any kind of distress, at any hour the services above are closed: 13 11 14
Palliative care is not the same as giving up on treatment, and it is not only for the last weeks of life. It is symptom and comfort care that can run alongside active treatment, including a clinical trial.
Outside Australia? The numbers above are Australian and will not work from overseas. Find a Helpline is a free directory of support and crisis lines in over 130 countries, run by ThroughLine with the International Association for Suicide Prevention.
Voxsanity is not a counselling or medical service, and nothing on this page is medical advice. More Australian services are listed on our support lines page.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
This date has passed while the registry still lists the trial as open to participants. Sponsors often update a trial's status without revising its projected end date, so it may well still be recruiting — but the record is out of date in at least one respect. Check with the study contact before relying on either.
Where this trial is recruiting
Primary endpoints
Change in Alzheimer's disease Assessment Scale-Cognitive Subscale 13 (ADAS-Cog13); Change in Montreal Cognitive Assessment (MoCA); Change in Mini-mental State Examination (MMSE); Change in Clinical Dementia Rating Scale sum of the boxes (CDR-SB); Change in Clinical Dementia Rating Scale global score (CDR-GS)
Can't join this trial?
Data last synced from ClinicalTrials.gov: 5 August 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.