Phase 2 Breast Cancer Trial, Not Yet Recruiting
voxsanity.com.au · Eligibility summary from public government registries · 18 August 2026 · not medical advice
Who may and may not be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who may be able to join
- The cancer has been confirmed by a pathologist as HER2-positive or HER2-low advanced breast cancer (based on specific test results).
- The person is older than 18 years.
- Brain metastases (cancer that has spread to the brain) have been newly diagnosed and confirmed by a special type of brain scan (enhanced MRI), with fewer than 6 areas of spread.
- The person has received no more than four previous treatment regimens for advanced disease.
- Life expectancy is more than 3 months.
- There are no known or suspected signs of cancer spreading to the lining of the brain or spinal cord (leptomeningeal metastases).
- At least 2 weeks have passed since the last treatment, and any side effects from previous treatment have mostly resolved.
- Certain medications (mannitol, bevacizumab, or hormone therapy) are permitted before joining, provided the dose has been stable for at least one week without needing to be increased.
- Recent blood test results must meet specific requirements for blood cell counts, liver function, kidney function, heart function, and clotting (confirm with trial site), and must have been taken within 28 days before registration.
- The person has read and signed a consent form before entering the trial.
Who may not be able to join
Each point below is a reason the trial team may not be able to accept someone. It is not a list of requirements to meet.
- Cancer has spread to the lining of the brain or spinal cord, or there is bleeding within the brain metastases.
- The person has previously been treated with a drug called T-DXd (trastuzumab deruxtecan).
- The person has epilepsy that is not well controlled.
- The person has severe or uncontrolled serious health conditions, such as serious heart disease, end-stage kidney disease, severe liver disease, a history of immune system problems (including HIV), active hepatitis B or C, other immune deficiency conditions, a history of organ transplant, or an active infection.
- The person has a known allergy to any of the treatments used in this trial.
- The person is pregnant or breastfeeding, or is a woman of childbearing age who is not willing to use contraception.
- The person is unable to undergo an enhanced MRI scan.
- The trial sponsor has identified specific reasons that make the person unsuitable for inclusion (confirm with trial site).
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Phone: 13971139665
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Primary endpoints
The objective response rate of intracranial（IC-ORR）
Can't join this trial?
Data last synced from ClinicalTrials.gov: 30 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.