Phase 2 Cardiomyopathy Trial, Recruiting NCT07023614 Sponsor: Imbria Pharmaceuticals, Inc. Condition: Cardiomyopathy
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Phase 2 Cardiomyopathy Trial, Recruiting

NCT07023614
Recruiting Phase 2

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • People who have been clinically diagnosed with hypertrophic cardiomyopathy (HCM), a condition where the heart muscle becomes abnormally thick, in line with recognised medical guidelines
  • People whose specific type of HCM (non-obstructive HCM) has been confirmed through ultrasound heart scans done at rest and during exercise, reviewed by a specialist imaging laboratory
  • People whose heart condition affects their daily activities at a moderate level, classified as Class II or III on a standard scale used by doctors to measure heart-related limitations
  • People who show a measurable reduction in physical ability, confirmed through a specialised exercise breathing test done during screening

Who may not be able to join:

  • People whose thickened heart muscle is caused by a known or suspected underlying condition such as a storage disorder or infiltrative disease, rather than non-obstructive HCM
  • People who have another condition that the trial doctor considers to be the main cause of their breathlessness, difficulty exercising, or chest pain
  • People who are unable to exercise on a treadmill or stationary bicycle, for example due to joint or movement problems
  • People who have a medical condition that prevents them from safely doing an upright exercise stress test

Other eligibility criteria set out in the trial protocol also apply, and the trial site will assess these during screening.

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 26 July 2026
Phase 2: approximately ~30% of drugs entering this phase reach regulatory approval, based on published industry-wide historical data. This is not specific to this trial.
Phase success rates shown are historical industry-wide averages based on published data. They are not a prediction for this specific trial or your individual situation.

Contact this trial

Phone: (617) 675-4060

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Phase 2
Sponsor
Imbria Pharmaceuticals, Inc.
Registry
ClinicalTrials.gov
Start date
6 October 2025
Est. completion
1 December 2026

Where this trial is recruiting

🇦🇹 Austria 🇧🇪 Belgium 🇫🇷 France 🇩🇪 Germany 🇮🇹 Italy 🇳🇱 Netherlands 🇵🇱 Poland 🇵🇹 Portugal 🇪🇸 Spain 🇬🇧 United Kingdom 🇺🇸 United States

Primary endpoints

Change in Kansas City Cardiomyopathy Questionnaire Clinical Summary Score (KCCQ-CSS)

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 26 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov