Phase 2 HIV and AIDS Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 40 or older, or people who have been living with HIV for 25 years or more, of any sex
• People whose HIV viral load is undetectable — meaning their last test result, taken within the past 6 months, showed fewer than 50 copies/ml
• People who have at least one heart or cardiovascular risk factor, such as: having lived with HIV for 25 years or more, high blood pressure, diabetes, current or past smoking, abnormal cholesterol or blood fats, a close family member (parent or sibling) who had heart disease at a young age (before 55 for males or before 65 for females), or a previously diagnosed heart condition such as a heart attack, stroke, a procedure to open blocked heart arteries, or confirmed significant narrowing of the heart arteries
• People with a previous heart condition must be in a stable condition, as assessed by the study doctors
• Any previous heart events must have occurred at least 3 months before the screening visit
• People who have had a detectable level of a specific HIV-related protein (called sgp120) in their blood at any point in the past year, tested at a specific laboratory (confirm with trial site)

Who may not be able to join:

• People with a known allergy to the study drug
• People currently taking certain medications that strongly affect how the body processes drugs — including some seizure medications (such as carbamazepine or phenytoin), a cancer treatment called mitotane, enzalutamide, the antibiotic rifampicin, or the herbal supplement St John's Wort
• People who are pregnant, breastfeeding, or planning to become pregnant; women who could become pregnant must have a negative pregnancy test at the start of the study and must use contraception throughout the treatment period
• People who cannot have a CT scan, either because their kidneys are not working well enough (confirm with trial site for specific measurement) or because of an allergy to iodine contrast dye
• People who, in the study doctor's judgement, have had a high level of radiation exposure outside of normal medical care in the past few years — for example, those with radiation exposure through their work or from multiple CT scans in previous research trials
• People with certain heart rhythm abnormalities detected on an ECG (specific measurements — confirm with trial site)
• People with a condition called long QT syndrome, whether present from birth or developed over time
• People currently taking or expected to take certain heart rhythm medications, including amiodarone, disopyramide, dofetilide, ibutilide, procainamide, sotalol, or quinidine
• People with serious, unstable liver disease involving complications such as fluid build-up in the abdomen, confusion caused by liver problems, poor blood clotting, low protein levels in the blood, untreated enlarged veins in the food pipe or stomach, persistently high bilirubin levels, or known bile duct problems (some exceptions may apply — confirm with trial site)
• People with significantly elevated liver enzyme levels on blood tests (confirm with trial site for specific values)
• People with severe liver scarring (cirrhosis) classified as Child-Pugh Class C
• People who are not able to give informed consent
• People whose life expectancy is estimated to be less than 36 months
• People who are not able to attend the required study visits
• People currently participating in another interventional clinical trial
• People with severe heart failure (classified as NYHA Class 3 or 4)

Important: Always verify eligibility with the trial site directly before applying.