Chronic Rhinosinusitis Trial, Not Yet Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are between 18 and 99 years old and willing to take part in the study
• You have been formally diagnosed with asthma by a doctor
• You are receiving treatment for severe asthma at the highest recommended treatment levels (known as GINA/DAL step 4 or 5)
• Your asthma is not well controlled despite taking high-dose inhaled medicines, shown by one or more of the following: a low asthma control score (ACT below 20 or ACQ above 0.75), needing steroid tablets at least twice in the past 12 months, being hospitalised for asthma in the past 12 months, or having reduced lung function (below 80% of what is expected for you)
• You have a specific marker of airway inflammation (called FeNO) of 20 or above, measured by a breathing test
• You have a raised level of certain immune cells (eosinophils) in your blood or airway samples, above set thresholds (confirm with trial site for exact values)
• You have a mucus score of 1 or higher, as assessed by the study team
• You have given your written agreement (informed consent) to take part before any study procedures begin
• If you have previously taken a biologic medicine (a type of specialist injection treatment) for asthma or nasal polyps, enough time must have passed since your last dose — at least 3 months or 3 times the medicine's half-life, whichever is longer (confirm with trial site)
• For one specific group in the trial: you have nasal polyps confirmed by a scan or camera examination of your nose

Who may not be able to join:

• You are currently taking a biologic medicine, or have taken one within the past 12 weeks, or have ever been treated with tezepelumab specifically
• You are pregnant (this will be checked with a urine test)
• You have a physical condition inside your nose or airways that would make it impossible to carry out the procedures required in the study (confirm with trial site)
• You have another serious lung condition such as bronchiectasis, pulmonary fibrosis, emphysema, cystic fibrosis, primary ciliary dyskinesia, or lung cancer
• You have any known parasitic infection
• Your nasal polyps are caused by something other than a specific type of airway inflammation called Type 2 inflammation (confirm with trial site)
• You have certain other conditions that can cause asthma-like symptoms and raised eosinophil levels, such as EGPA, allergic bronchopulmonary aspergillosis, or hypereosinophilic syndrome (confirm with trial site)
• There are medical reasons why it would not be safe for you to have a small tissue sample (biopsy) taken from your airways
• You have a mental health condition that makes it difficult to fully understand what taking part in the study involves
• You have other significant health conditions that the study team considers would affect your participation (confirm with trial site)
• You are taking immunosuppressant medicines such as cyclosporine
• You currently misuse drugs or alcohol
• You are a current smoker, or you stopped smoking less than 6 months ago

Important: Always verify eligibility with the trial site directly before applying.