Phase 2 Liver Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults between 16 and 85 years old who have severe liver disease or sudden liver failure and have been assessed as needing a liver transplant.
• A donor liver from a deceased donor has been allocated and is available to be used in the study after the gene editing process.
• No perfectly tissue-matched (HLA-matched) donor liver is immediately available — as the trial is designed for people receiving a liver that is not a perfect tissue match, most people waiting for a transplant are likely to meet this condition (confirm with trial site).
• The person has been assessed as medically suitable for transplant surgery and able to tolerate the standard anti-rejection medicines used after a transplant.
• The person is able to understand that this is an investigational (research) trial and is willing to sign a written consent form, including agreeing to receive a genetically modified organ and to be followed up long-term with regular blood tests and tissue samples.
• The person is willing and able to attend all required study visits and follow-up appointments for the full duration of the trial.

Who may not be able to join:

• People with a serious, uncontrolled infection — such as blood poisoning (sepsis) or active tuberculosis — that would increase the risks of transplant surgery or affect how results are measured.
• People with HIV or other ongoing viral infections that are not well managed. People with hepatitis B or C may still be considered if their infection is well controlled, but active, replicating virus at the time of transplant would be a concern (confirm with trial site).
• People who need more than just a liver transplant — for example, someone who needs both a liver and a kidney transplant at the same time — as the trial is only looking at liver transplants on their own.
• People who are pregnant or breastfeeding. Women who could become pregnant must have a negative pregnancy test before the transplant and must agree to use reliable contraception, as the effects of a gene-edited organ and anti-rejection medicines on a pregnancy or infant are not known.
• People with a serious illness unrelated to their liver disease that is expected to severely limit their life expectancy or make them unsuitable for surgery — for example, advanced heart failure or poorly controlled diabetes with complications.
• People with a known severe allergic reaction to any of the substances used in the gene editing process (confirm with trial site for specific details).
• People who are unable to follow the trial's strict monitoring schedule due to mental health, personal, or practical reasons — for example, having no reliable way to travel to appointments or no support network to help them attend.

Important: Always verify eligibility with the trial site directly before applying.