Phase 2 Liver Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You must be at least 18 years old.
• You must be willing and able to sign a consent form agreeing to take part.
• You have been diagnosed with liver cancer (hepatocellular carcinoma/HCC) that has spread or cannot be removed by surgery, confirmed by a tissue sample or by standard diagnostic criteria used by liver disease specialists.
• Your liver cancer got worse after receiving a specific type of previous treatment combining an immunotherapy drug (anti-PD1/PD-L1) and a drug called bevacizumab.
• You have at least one tumor that can be measured on a scan, which has either not been treated locally before, or has grown again after local treatment.
• Your liver function and overall health fall within acceptable ranges as measured by specific scoring systems (Child-Pugh score of 5–7 and an activity/fitness score of 2 or less on the ECOG scale).
• If you have a chronic hepatitis B infection, your virus levels must be very low (below 100 IU/mL at screening) and you must already be on antiviral medication.
• Your doctors expect you to live for at least 12 weeks.
• Your blood counts, liver enzymes, and kidney function must meet specific acceptable levels (confirm with trial site for exact values).
• If you are a woman who could become pregnant, you must have a negative pregnancy test within 7 days before starting the trial.
• You must be willing and able to follow all trial requirements, including attending appointments, following contraception guidelines, and completing all follow-up visits.

Who may not be able to join:

• You have a specific rare subtype of liver cancer (fibrolamellar HCC, sarcomatoid HCC, or a mixed type involving bile duct cancer).
• You are on a waiting list for a liver transplant or have very advanced liver disease.
• You have a significant history of heart disease or have had a serious gastrointestinal bleed within the past 4 weeks.
• You have had a blood clot or stroke (including mini-strokes or blood clots in the lungs or legs) within the past 6 months, with a specific exception for certain types of blood clots in the liver's portal vein (confirm with trial site).
• You currently have or have had a second type of cancer, unless it was an early-stage skin cancer or a very early cervical cancer that has been fully treated.
• You have HIV or another condition that weakens your immune system.
• You have taken part in another clinical trial using an experimental treatment within the past 30 days (or longer, depending on the previous treatment — confirm with trial site).
• You have certain other health conditions or complications, including: a history of serious lung inflammation, a combined hepatitis B and C infection, known inflammation of the pancreas, active tuberculosis, any active serious infection needing treatment, a history of organ or tissue transplant, a condition requiring immune-suppressing medication, an active autoimmune disease requiring treatment within the past 3 months (some exceptions apply — confirm with trial site), cancer spread to the brain (with some exceptions for those who have completed treatment and have no symptoms — confirm with trial site), or a live vaccine received within the past 30 days.
• You are currently taking any medication known to interfere with the drugs used in this trial.
• You are receiving any other cancer treatment not specified by this trial.
• You have taken any other experimental treatment within the past 28 days.
• You are pregnant, breastfeeding, or unwilling or unable to use a reliable form of birth control (specific acceptable methods are listed — confirm with trial site).
• You have a significant history of not following medical instructions or are unable to give informed consent reliably.

Important: Always verify eligibility with the trial site directly before applying.