Phase 2 Liver Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 18 to 75 years old
• People who have been diagnosed with advanced liver cancer (hepatocellular carcinoma) confirmed by a tissue biopsy or sample
• People whose cancer can be measured on a scan using standard medical criteria
• People whose cancer has continued to grow or spread after at least 2 previous cancer treatments
• People expected to live for at least 6 months
• People who are generally well enough to carry out light activity and care for themselves (a doctor will assess this using a standard scale)
• People who have tumor tissue available for detailed genetic testing, or who already have qualifying genetic test results on file
• People whose blood counts, liver function, kidney function, and blood clotting results fall within the ranges required by the trial (a doctor will check these through blood tests)
• Women who could become pregnant must have a negative pregnancy test within 7 days before starting treatment, and must agree to use highly effective contraception during the trial and for at least 120 days after the last treatment
• Men must agree to use barrier contraception during the trial and for at least 120 days after the last treatment
• People who are willing and able to attend all required visits, follow the study schedule, and complete all required tests and procedures

Who may not be able to join:

• People who have had another active cancer in the past 5 years, unless it was a type of skin cancer that has been fully treated, early-stage cervical changes, or another cancer considered fully cured with very low chance of returning
• People whose genetic testing does not find specific targets needed for the trial's treatment approach
• People who have previously had a bone marrow, stem cell, or solid organ transplant from another person
• People who have cancer that has spread to the brain or spinal fluid that is currently active or causing symptoms — previously treated and stable brain metastases may be considered in some cases (confirm with trial site), but spread to the lining of the brain or spinal cord is not permitted under any circumstances
• People with an active bacterial, fungal, or mycobacterial infection that requires treatment, including untreated latent tuberculosis
• People with certain active viral infections, including detectable hepatitis B virus, detectable hepatitis C virus, HIV, or active syphilis
• People who have an active autoimmune disease that has required higher-dose immune-suppressing medication within the past 2 years — some conditions such as vitiligo, type 1 diabetes, stable thyroid conditions on medication, and mild psoriasis may still be considered (confirm with trial site)
• People who have taken higher-dose immune-suppressing medication within 14 days before the planned treatment (low-dose topical, inhaled, or eye drop steroids are generally permitted)
• People with serious uncontrolled heart conditions, uncontrolled high blood pressure, or significant lung disease
• People with a history of substance use or a mental health or social situation that would make it difficult to give informed consent or follow the study requirements
• People who have had a severe allergic reaction (grade 3 or higher) to a vaccine or similar investigational product, or who have any condition the trial doctor considers too risky for immunotherapy
• People who have any other condition that, in the trial doctor's judgment, could affect their safety or the reliability of the trial results

Important: Always verify eligibility with the trial site directly before applying.