Phase 3 Chronic Rhinosinusitis Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You weigh at least 40 kg (about 88 pounds)
• You have been diagnosed with chronic rhinosinusitis with nasal polyps (a long-term sinus condition where growths develop inside the nose)
• You have nasal polyps in both nostrils, with scores meeting a minimum level of severity as measured by your doctor at two separate visits
• Your nasal congestion/blockage symptoms score at or above a certain level of severity at two separate visits
• Your overall sinus-related quality of life score (a standard questionnaire) is at or above a certain level at two separate visits
• You have had ongoing nasal polyp symptoms for more than 4 weeks before your screening appointment
• You have already tried using a steroid nasal spray as part of your treatment before joining the trial
• You have either had nasal polyp surgery in the past, used steroid tablets/pills for this condition within the last year, or have a medical reason why you cannot use steroid tablets/pills

Who may not be able to join:

• You have other health conditions that could affect how nasal polyp treatment results are measured
• You have other health conditions (apart from asthma) that could affect the level of certain white blood cells in your blood
• You have a weakened immune system
• You have a condition that means a camera examination inside your nose would not be safe or suitable for you
• You have high blood pressure or diabetes that is not well controlled
• You have had an active infection in the 4 weeks before joining the trial
• You have had uncontrolled nosebleeds in the 4 weeks before joining the trial
• You have had major surgery in the 3 months before joining, have surgery planned during the study, or are receiving treatments that could affect the study results
• You have had a parasitic infection in the 6 months before joining the trial
• You have had sinus or nasal surgery in the 6 months before your screening visit, or that surgery has changed your nasal structure in a way that makes assessment impossible
• You have been diagnosed with cancer in the past 5 years (except certain low-risk types — confirm with trial site)
• You have abnormal results from blood or other lab tests at your screening or baseline visits
• You currently have active hepatitis B, or test positive for hepatitis C, HIV, or syphilis antibodies
• You have an abnormal heart rhythm or electrical signal on a heart tracing (ECG) that could pose a safety risk
• Your lung function (a specific breathing test result) is below 50% of the expected level at screening
• You have received a blood transfusion or immunoglobulin treatment in the 4 weeks before joining
• You have used steroid tablets/pills or additional steroid nasal sprays in the 4 weeks before joining, or plan to use them during the study
• You regularly use nasal or oral decongestant medicines in the 4 weeks before joining (other than during a camera nose examination)
• You have received a live or viral vector vaccine in the 4 weeks before joining
• You have had allergy immunotherapy (allergy shots or similar treatment) in the 8 weeks before joining
• You are currently smoking, or you stopped smoking less than 6 months before your screening visit
• You have misused substances, drugs, or alcohol excessively in the year before joining
• You are pregnant, breastfeeding, have a positive pregnancy test at screening or baseline, or plan to become pregnant during the study

Important: Always verify eligibility with the trial site directly before applying.