Phase 2 Rheumatoid Arthritis Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have moderate to severe active rheumatoid arthritis (RA), with at least 6 swollen joints and at least 6 tender joints measured at two separate check-in appointments.
• People who have had a formal diagnosis of RA for at least 3 months, and whose diagnosis meets the 2010 international classification standards for RA.
• People whose RA did not respond well enough to, stopped responding to, or who could not tolerate at least one standard RA medication (known as a conventional DMARD).

Who may not be able to join:

• People who have already tried and not responded to more than two TNF inhibitor or JAK inhibitor medications.
• People whose RA is classified as the most severe functional stage (Class IV), meaning they have very limited ability to perform self-care, work, or other activities.
• People who have previously used or are currently using certain biological RA medications (called bDMARDs), other than TNF inhibitors, or who have been treated with rituximab.
• People who have taken part in another clinical trial and received an experimental treatment within the past 4 weeks, or within 5 half-lives of that treatment, whichever period is longer.
• People who have a history of any form of arthritis that started before age 17, or who currently have a different type of inflammatory joint condition other than RA.
• People who have received corticosteroid injections (into a joint, muscle, vein, or surrounding tissue) within the 8 weeks before the first dose of the trial drug.
• People with a history of a severe allergic or anaphylactic reaction, or a known sensitivity to any ingredient in the trial drug or other medications in the same class.
• People who have had major surgery within 6 weeks before the screening appointment, or who have major surgery planned during the trial period.
• People who have a serious, long-term, or unstable medical or psychiatric condition of any kind.
• People with a history of cancer, except for certain treated and resolved skin cancers (such as basal cell carcinoma or squamous cell skin cancer) or fully treated and cleared cervical cancer in situ.
• People who have severe, ongoing, or frequently recurring infections caused by viruses, bacteria, parasites, or fungi.
• People with a history of active hepatitis B, hepatitis C, or HIV infection.
• People who have had an organ transplant.
• People with a confirmed inherited or acquired immune system deficiency.
• People with abnormal blood test results or abnormal liver function test results (confirm with trial site for specific thresholds).

Important: Always verify eligibility with the trial site directly before applying.