Phase 4 Liver Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with liver cancer (hepatocellular carcinoma, or HCC) through scans and blood tests, and your doctors believe you can have keyhole (laparoscopic) surgery to remove part of your liver
• Your planned surgery involves removing either a larger portion of the liver (at least 3 sections) or a smaller portion (no more than 2 sections)
• During surgery, a specific technique to temporarily cut off blood flow to the liver will be used — each pause lasts no more than 15 minutes and is done between 2 and 4 times
• You are between 18 and 80 years old, of any gender, and have a Body Mass Index (BMI) between 18.5 and 28
• Your liver is functioning reasonably well, based on specific medical scoring systems (Child-Pugh grade A or B with a score of 7 or less; ASA grades I to III) (confirm with trial site)
• A special liver function test (ICG R15) shows your result is below 10%, and enough healthy liver will remain after surgery (confirm with trial site)
• You have a single liver tumour smaller than 10 cm, with no spread to other parts of the body or to the main blood vessels of the liver
• Your liver enzyme levels (ALT) before surgery are within an acceptable range (less than twice the normal upper limit)
• You have not had a procedure to block a vein near the liver before joining; if you have had a certain type of liver treatment (TACE), it was completed more than 6 months ago; if you have had other anti-cancer drug treatment, it was completed more than 4 weeks ago
• You have not taken any medicines known to harm the liver in the two weeks before joining

Who may not be able to join:

• You have damage to the blood vessels supplying the remaining part of your liver, such as a blockage, ligation, or clot
• You have a blood clotting problem (your clotting time is more than 3 seconds longer than normal)
• You have obstructed bile flow (jaundice), serious heart disease, serious kidney disease, or other severe health conditions
• Microwave treatment is used during your surgery (either alone or alongside the procedure)
• During surgery, blood flow to the liver needs to be stopped more than 4 times, or any single pause lasts longer than 15 minutes
• The type of liver surgery performed is not "anatomical" (meaning it does not follow the liver's natural structure), and large areas of the remaining liver are left without proper blood supply
• You need more than 1,000 ml of blood transfusion during surgery
• During surgery, a problem is found in another organ (other than the gallbladder) that also needs to be removed
• During surgery, additional liver problems are found that require extra procedures such as tumour burning (ablation) or bowel-to-bile-duct connection surgery
• You have a condition such as chronic kidney disease, an inflammatory condition, or an immune system disorder that has previously required long-term steroid (glucocorticoid) treatment
• You have a serious mental health condition or severe anxiety that would make it difficult to take part in the trial
• You have taken part in another clinical trial within the past 3 months
• You are allergic or sensitive to benzoic acid or to the study drug used in this trial
• You are pregnant or breastfeeding
• The trial team believes there is any other reason you would not be suitable for this trial (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.