Phase 3 Liver Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You had surgery to completely remove liver cancer (hepatocellular carcinoma), and the edge of tissue removed around the tumor was less than 1 cm wide, confirmed by lab results, surgical notes, and scans
• Your surgery took place within the last 4 months
• You have at least one additional factor that raises the risk of the cancer coming back — such as cancer found in small blood vessels near the tumor, a blood clot caused by the tumor, small satellite tumors nearby, a blood protein called AFP being above 400 ng/mL before surgery, or a tumor larger than 5 cm without a complete outer layer
• You are between 18 and 80 years old
• You are generally active and able to carry out daily activities with little to no limitation (confirm with trial site)
• Your liver is functioning at an acceptable level, based on a standard liver scoring system (confirm with trial site)
• You have had a special liver MRI scan after surgery to confirm no cancer remains in the liver
• If you have hepatitis B or C, your liver enzyme levels must be within a certain range and you must be receiving antiviral treatment
• Your liver enzyme levels (from a blood test) are within the ranges required by the trial
• You have no serious heart problems or abnormal heart rhythm readings on an ECG
• Your kidney function levels from blood tests are within an acceptable range
• Your blood counts (red blood cells, white blood cells, and platelets) meet the minimum levels required
• You are willing and able to give written consent to take part

Who may not be able to join:

• You had a significant tumor blood clot in the main portal vein or the large vein leading to the heart, seen on scans before surgery
• You have previously received treatments for liver cancer such as targeted therapy drugs, immunotherapy (e.g. PD-1 or PD-L1 inhibitors), or chemotherapy
• Your cancer had already spread to other parts of the body before joining the trial
• You have moderate to severe fluid build-up in your abdomen that does not respond to treatment
• You have a history of another type of cancer, unless it was a very early-stage or non-invasive cancer such as early thyroid cancer or a type of skin cancer (confirm with trial site)
• You have previously had radiotherapy to your abdomen
• You have serious problems with your heart, kidneys, or other major organs
• You have an active autoimmune disease or a significant mental health condition
• You are living with HIV
• You are pregnant or currently breastfeeding
• You are already taking part in another clinical trial that involves a treatment intervention

Important: Always verify eligibility with the trial site directly before applying.