Phase 3 Heart Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are older than 18 years of age.
• You have stable coronary artery disease (a long-term, non-emergency heart condition) and are scheduled for bypass heart surgery (CABG) with at least 2 bypass grafts planned.
• Your blocked heart arteries have been confirmed by specific heart imaging or pressure tests (confirm with trial site for exact measurements).
• You are able and willing to follow all study procedures and attend all follow-up appointments.
• You have read and signed a consent form agreeing to take part in the study.
• During your surgery, blood flow measurements in all bypass grafts came back within acceptable ranges.
• The main heart artery at the front of your heart (left anterior descending artery) was bypassed using an artery from inside your chest wall.
• No additional unplanned procedures were performed during your surgery (such as valve repair or other interventions).
• No special cleaning of the bypassed artery (called endarterectomy) was needed during surgery.

Who may not be able to join:

• You are currently in cardiogenic shock (your heart is not pumping enough blood to meet your body's needs).
• You have had a heart attack or serious heart event in the past 12 months.
• You only need one bypass graft.
• You have an irregular heart rhythm called atrial fibrillation before surgery.
• You are on dialysis (kidney treatment machine).
• Your blood platelet count is too low (low levels of the cells that help your blood clot).
• You have anaemia (low levels of red blood cells or haemoglobin).
• You have severe liver disease.
• You have an active infection with HIV, Hepatitis B, Hepatitis C, or tuberculosis.
• You currently have cancer or have been treated for cancer within the past 5 years.
• You need to take two blood-thinning medications together (called dual antiplatelet therapy) for another medical reason, such as a recent stent.
• You need to take blood-thinning medication (anticoagulants) by mouth for another reason.
• You are taking or need to take methotrexate (a medication used for some cancers or inflammatory conditions) at a dose of 15 mg per week or more.
• You have a known allergy or medical reason preventing you from taking prasugrel or aspirin.
• You are scheduled for another heart or non-heart surgery within the next 12 months.
• You have a non-heart-related illness where life expectancy is less than 12 months.
• You have previously had serious bleeding while taking dual blood-thinning medications.
• You have had bleeding inside the brain at any point in the past.
• You have had bleeding in your stomach or digestive system at any point in the past.
• You are pregnant or breastfeeding.
• You are not using a reliable method of contraception (if applicable) (confirm with trial site).
• Your kidneys are not functioning well enough (confirmed by a specific kidney function test result).
• After your surgery and before being enrolled in the study, you experienced serious complications such as a heart attack, stroke, severe heart pump failure, new irregular heartbeat, or digestive bleeding.

Important: Always verify eligibility with the trial site directly before applying.