Phase 2 Alzheimer's Disease Trial, Not Yet Recruiting
voxsanity.com.au · Eligibility summary from public government registries · 18 August 2026 · not medical advice
Who may and may not be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who may be able to join
- The person must be able to understand and agree to take part in the study (give informed consent).
- There must be someone in the person's life who can act as a reliable study partner and has regular contact with them.
- The person must have a diagnosis of Alzheimer's disease based on the revised NIA-AA guidelines.
- The person must be 50 years of age or older.
- The person must score 18 or above on a standard memory and thinking test called the Mini-Mental State Examination (MMSE), and be likely to complete all study assessments.
- The person must score 4 or below on a scale used to assess whether strokes or blood vessel problems may be contributing to memory difficulties (the Rosen Modified Hachinski Ischemic score).
- The person must have been on a stable medication routine for at least 2 months before the screening visit, whether or not they are taking memory medications called cholinesterase inhibitors.
- The person must be fluent in English and show signs of having had adequate intellectual functioning before their illness began.
- The person must be likely to attend all scheduled study visits and complete all required tests.
Who may not be able to join
Each point below is a reason the trial team may not be able to accept someone. It is not a list of requirements to meet.
- People with any medical reasons that would make taking oral semaglutide (a medication) unsafe for them.
- People with a significant brain or nervous system condition other than Alzheimer's disease that may affect thinking and memory.
- People whose brain scan (MRI or CT) clearly shows that their memory problems are caused by blood vessel disease in the brain, or who meet the criteria for a diagnosis of vascular dementia.
- People who currently have a clinically significant major mental health condition.
- People who currently have a significant physical illness that is likely to worsen their condition or affect their safety during the study.
- People who have had a heart attack within the past year.
- People with any other significant abnormality found during a physical, neurological, or laboratory examination that could affect the study or the person's wellbeing.
- People with a history of alcohol or drug dependence within the past 2 years.
- People currently using strong pain-relieving medications (narcotics) that could affect thinking and memory.
- Women who are able to become pregnant (confirm with trial site regarding contraception requirements and pregnancy testing before any PET scan).
- People with any medical reasons that would make having an MRI scan unsafe for them.
- People with a history of pancreatitis (inflammation of the pancreas) or gallstones, as confirmed by ultrasound or hospital admission.
- People with a history of medullary thyroid cancer.
- People who have been diagnosed with type 2 diabetes and are unwilling to change their current diabetes treatment to semaglutide.
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Phone: +44 2075941083
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Primary endpoints
To evaluate the safety and tolerability of oral semaglutide in an AD population.
Can't join this trial?
Data last synced from ClinicalTrials.gov: 14 August 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.