Phase 2 Sleep Disorders Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People whose memory and thinking test results fall above the threshold for dementia (as measured by standard cognitive tests, such as the MoCA, MMSE, or Clinical Dementia Rating scale)
• People who have completed at least 6 years of formal schooling
• People who have been on a stable dose of any psychiatric medications for at least 1 month before the screening visit, with no planned changes to that dose during the study
• People who are able to read and sign a consent form in English or French

Who may not be able to join:

• People who have a formal diagnosis of a major disorder affecting memory and thinking (such as dementia)
• People with an unstable psychiatric condition
• People with clinically significant active thoughts of suicide
• People with an unstable medical condition, as determined by the trial investigator
• People with a known or suspected history of drug or alcohol dependence or misuse within the past year
• People who are currently taking a type of sleep medication called a DORA (dual orexin receptor antagonist) (confirm with trial site)
• People who have a known allergy or serious adverse reaction to a DORA medication
• People who have been using benzodiazepines or "z-drugs" (a type of sleep medication) more than twice a week in the past month
• People who are taking certain medications that strongly affect how the liver processes drugs, known as major or moderate CYP3A4 inducers or inhibitors (confirm with trial site)
• People who are taking strong medications that slow down the central nervous system, including opioid painkillers, strong analgesics, antipsychotics, or sedating antidepressants
• People who are currently using medications called cholinesterase inhibitors or memantine (commonly used for dementia)
• People who are pregnant or currently breastfeeding
• People with severe obstructive sleep apnea (a condition where breathing repeatedly stops during sleep)
• People with a clinically significant and untreated sleep disorder involving unusual movements or behaviours during sleep, restless leg syndrome, or other abnormal sleep behaviours
• People who have been diagnosed with narcolepsy (a condition causing sudden and uncontrollable episodes of sleep)

Important: Always verify eligibility with the trial site directly before applying.