Phase 1 Heart Disease Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 50 or older at the time of signing the consent form
• People who have been diagnosed with a type of heart failure called HFpEF, based on recognised medical guidelines
• People whose heart failure symptoms fall into a moderate category known as NYHA Class II or III (confirm with trial site)
• People whose heart pumping function (measured by a heart ultrasound) shows a result of 50% or higher, along with signs of heart failure
• People who have an elevated level of a heart stress marker called NT-proBNP on a blood test at the screening visit
• People who have a level of a specific protein marker called NordicPRO-C6™ of 11 ng/mL or higher at the screening visit
• People who have been on a stable dose of all their heart failure medicines for at least 4 weeks before the screening visit
• People who weigh at least 110 lbs (50 kg) and have a body mass index (BMI) between 18 and under 45
• Male participants who agree to the trial's contraception requirements, and female participants who are not able to become pregnant
• People who are able to understand and willing to sign a written consent form
• People who are willing and able to follow all trial procedures and requirements

Who may not be able to join:

• Women who are pregnant or breastfeeding
• People who have a known allergy or sensitivity to the study drug, VS-041
• People who have heart or blood vessel conditions other than HFpEF
• People who have an active illness at the time of screening, such as a current bacterial or viral infection
• People with a history of illicit drug or alcohol misuse that the lead doctor believes could affect their ability to participate
• People who have an active ongoing viral infection such as Hepatitis B, Hepatitis C, or HIV at the time of screening
• People whose heart failure has recently worsened severely within the 30 days before the screening visit
• People who have had a lung disease within the 12 months before the screening visit
• People with a current, untreated, or recently treated cancer (less than 5 years in remission from a significant cancer)
• People with any other condition, including mental health conditions, that the lead doctor believes would prevent them from completing the trial
• People who have taken part in another clinical trial involving an experimental treatment within the last 6 months
• People who, for any other reason, the lead doctor believes should not participate in the trial

Important: Always verify eligibility with the trial site directly before applying.