Liver Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults aged 18 or older who are expected to live for at least one year
• People who have been diagnosed with liver cancer (hepatocellular carcinoma), confirmed through specific imaging results, a tissue biopsy, or through a combination of liver scarring (cirrhosis) and a raised level of a liver cancer marker in the blood (AFP above 400)
• People whose cancer has not spread into major blood vessels or to other parts of the body, and who have up to 5 liver tumours, where at least one tumour is between 2 and 5 cm in size and none are larger than 5 cm
• People whose tumour location is considered safe and technically suitable for a needle-based heat treatment (percutaneous thermal ablation), as assessed by a specialist doctor
• People who are generally well enough to carry out most daily activities, with a physical ability rating of 0–2 on a standard medical scale (ECOG 0–2) (confirm with trial site)
• People whose blood clotting levels meet specific thresholds: platelets at or above 50,000/μL and a clotting measure (INR) at or below 1.8, or correctable to that level
• People who are able to have a contrast-enhanced CT or MRI scan
• People who are willing and able to give informed consent to take part

Who may not be able to join:

• People who have already had a previous treatment (such as ablation, chemoembolisation, radiation, or surgery) to the target tumour or to a tumour within 1 cm of it
• People who have more than 5 liver tumours, or where any tumour cannot be fully treated with ablation
• People with uncontrolled liver failure, including ongoing confusion caused by liver disease (hepatic encephalopathy)
• People with blood clotting problems that cannot be corrected, or other reasons why a needle-based liver procedure would not be safe
• People who cannot safely have contrast-enhanced imaging — for example, due to severe kidney disease without dialysis, or a contrast dye allergy that cannot be managed with pre-treatment medication
• People with an active infection anywhere in the body
• People who are pregnant
• People who would not be able to attend the required follow-up scans after treatment

Important: Always verify eligibility with the trial site directly before applying.