Phase 2 Liver Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are 18 years of age or older at the time of screening
• People who have been diagnosed with advanced or metastatic liver cancer (hepatocellular carcinoma), confirmed either by tissue/cell sample testing or, for those with liver scarring (cirrhosis), by established clinical guidelines
• People whose liver cancer cannot be treated with surgery or local treatments, or whose cancer has come back or progressed after those treatments
• People who have at least one measurable tumour that has not yet been treated
• People whose liver and kidney are functioning at an adequate level (confirm with trial site)
• People who have not previously received any systemic (whole-body) drug treatment for their liver cancer
• People who are relatively physically active and able to carry out daily activities, rated 0 or 1 on a standard medical scale (ECOG scale)
• People whose liver disease is classified as Child-Pugh Class A, meaning the liver is still functioning reasonably well

Who may not be able to join:

• People with moderate or severe fluid build-up in the abdomen (ascites)
• People with a history of confusion or brain problems caused by liver disease (hepatic encephalopathy)
• People with known active cancer spread to the brain, spine, or surrounding tissues
• People considered to have a significant risk of serious bleeding or abnormal connections between body passages (fistula)
• People who have had another type of cancer within the past 3 years
• People who have previously had an organ transplant or a bone marrow/stem cell transplant from a donor
• People who have an autoimmune disease (where the immune system attacks the body) that has required ongoing medical treatment within the past 2 years
• People who have had a significant heart or blood vessel problem within the 6 months before starting the trial
• People who have had major surgery or a serious injury within 4 weeks before starting the trial, or who have major surgery planned during the study period
• People with a history of serious bleeding problems or blood clotting disorders
• People who have had serious stomach or bowel problems — such as severe ulcers, open wounds, bowel perforation, abscesses, blockages, or significant bleeding including from swollen veins in the food pipe or stomach — within the 6 months before starting the trial
• People with a current active infection, whether short-term, long-term, or causing symptoms
• People with a history of a weakened immune system (immunodeficiency)

Important: Always verify eligibility with the trial site directly before applying.