Phase 2 Depression and Anxiety Trial, Not Yet Recruiting
voxsanity.com.au · Eligibility summary from public government registries · 18 August 2026 · not medical advice
Who may and may not be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who may be able to join
- People aged 18 or older
- People who can speak, read, and understand English
- People who are in generally stable health
- People who have treatment-resistant depression, meaning they score in the moderate or above range on a standard depression rating scale (called the HDRS) and have tried two or more antidepressant treatments without sufficient success in the last two years
Who may not be able to join
Each point below is a reason the trial team may not be able to accept someone. It is not a list of requirements to meet.
- People with uncontrolled high blood pressure
- People with heart problems, including an abnormal heart tracing (ECG) in the month before screening
- People with Chronic Obstructive Pulmonary Disease (a long-term lung condition)
- People with Congenital Long QT Syndrome (an inherited heart rhythm condition)
- People who weigh 265 pounds (120 kg) or more
- People with severe obesity, defined as a BMI of 40 or above
- People with increased pressure in the brain or around the spinal cord
- People who are pregnant or breastfeeding
- People with an overactive thyroid (hyperthyroidism)
- People who have previously had a bad reaction to ketamine, including an allergic reaction
- People experiencing symptoms of psychosis or early warning signs of psychosis
- People with a severe personality disorder
- People with an Autism Spectrum Disorder
- People with bipolar disorder
- People with a history of substance abuse, defined as a score of three or more on a standard drug use screening tool (note: prior use of psychedelics is allowed)
- People who have attempted suicide in the past year, or who are currently having thoughts of suicide with intent to act on them
- People who are not suitable for MRI scanning, including those with any metal implants, abnormalities of the brain or skull, large tattoos covering significant body areas, or claustrophobia (fear of enclosed spaces)
- People taking medications that may interact with ketamine — a full review of each person's current medications will be carried out by the trial site before admission (confirm with trial site for specific medications)
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
If you need support right now
This page includes language about suicide and self-harm, because that is how the trial's eligibility criteria are written. If reading it has been hard, you do not have to keep going. The services below are free, confidential, and answered by people trained for exactly this.
If you or someone else is in immediate danger, call 000.
- Lifeline — 24/7 crisis support: 13 11 14
- Suicide Call Back Service — 24/7 counselling: 1300 659 467
- 13YARN — 24/7, for Aboriginal and Torres Strait Islander people: 13 92 76
- Beyond Blue — 24/7 mental health support: 1300 22 4636
- Emergency: 000
Outside Australia? The numbers above are Australian and will not work from overseas. Find a Helpline is a free directory of crisis lines in over 130 countries, run by ThroughLine with the International Association for Suicide Prevention. If you are in immediate danger, call your local emergency number.
Voxsanity is not a crisis service, and nothing on this page is medical advice. More Australian services are listed on our support lines page.
Contact this trial
Phone: 585-275-4424
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Proportion of Participants Retained in Study Through 2-Month Follow-Up; Mean Change in Hamilton Depression Rating Scale (HDRS) Total Score
Can't join this trial?
Data last synced from ClinicalTrials.gov: 28 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.