Phase 4 Sjogren's Syndrome Trial, Recruiting NCT07277257 Sponsor: Center For Sight Condition: Sjogren's Syndrome
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Phase 4 Sjogren's Syndrome Trial, Recruiting

NCT07277257
Recruiting Phase 4

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • You are 18 years old or older and have been diagnosed with dry eye disease caused by Sjögren's Syndrome within the last 2 years.
  • You have used or wanted to use artificial tears (eye drops for dryness) for your dry eye symptoms at some point in the last 2 months.
  • Your eyes show a certain level of dryness and surface damage, measured by two specific eye tests done without numbing drops — your results must fall within a particular range (confirm with trial site).

Who may not be able to join:

  • You have had eye surgery in the last 6 months.
  • You have worn contact lenses within the 7 days before your first visit, or you plan to wear them during the study.
  • You have been on your current eye drop treatment for less than 3 months, or you expect to change your eye treatment during the study.
  • You have used steroid eye drops or a specific type of nasal spray (varenicline) within the last 4 weeks before starting the study, or you plan to use them during the study.
  • You have used artificial tears within 2 hours before any of your study visits.
  • You have a known allergy to any ingredient in the study medication (confirm with trial site).
  • You have a severe autoimmune condition (such as rheumatoid arthritis or lupus) that is not well controlled.

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 28 July 2026
Phase 4 trials study a drug that has already been approved, monitoring long-term safety and effectiveness in real-world use.

Contact this trial

Phone: 9412634784

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Phase 4
Sponsor
Center For Sight
Registry
ClinicalTrials.gov
Start date
2 December 2025
Est. completion
31 December 2026

Where this trial is recruiting

🇺🇸 United States

Primary endpoints

Change from pre-instillation to 3 minutes post-TRYPTYR instillation in study eye unanesthetized Schirmer's test at Visit 1 (baseline)

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 28 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov