Chronic Rhinosinusitis Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are 18 years old or older
• You have been officially diagnosed with chronic rhinosinusitis (a long-term sinus condition) according to recognized medical guidelines
• A CT scan taken within the last 6 months shows sinus disease affecting both sides of a specific sinus area (the ethmoid sinuses, located between your eyes), and this scan was taken at least 6 months after any previous sinus surgery if you have had one
• The same CT scan also shows disease affecting both of your frontal sinuses (located in your forehead) or the passages leading to them
• Your sinus symptom score on a standard questionnaire (called SNOT-22) is 30 or higher, meaning your symptoms are significantly affecting your quality of life
• Previous treatments such as medications have not worked well enough, and your doctor considers you a suitable candidate for sinus surgery on both sides
• You are willing and able to sign a consent form agreeing to take part
• You are willing and able to attend all required follow-up appointments and assessments during the study

Who may not be able to join:

• You have a tumor (cancerous or non-cancerous) inside your nasal cavity
• You have a specific type of nasal polyp called antrochoanal polyps
• You have previously had a full removal of a structure inside your nose called the middle turbinate
• There are signs or suspicion of a serious fungal sinus infection, such as bone damage on your CT scan or dead tissue in the sinuses
• You have a history of a gap in the thin bone near your sinuses or a leak of the fluid that surrounds your brain and spinal cord
• You are currently receiving chemotherapy or immunotherapy for another condition
• Your symptoms are currently too severe to safely have surgery (for example, a very high fever over 102.5°F, or serious complications such as an eye or brain infection, blood clot, or confusion)
• You have previously had complications from sinus surgery or balloon sinus procedures, such as a spinal fluid leak or injury to the skull base or eye area
• You have a condition called primary ciliary dyskinesia, which affects tiny hair-like structures in the airways
• You have a condition that requires you to regularly take steroid tablets to manage it, such as a certain type of lung disease (confirm with trial site)
• There is significant damage, ulceration, or erosion of the tissue inside your nose found during a nasal examination
• You have had an active nasal or upper respiratory infection, including COVID-19, within the 2 weeks before your first study appointment
• You are allergic or have had a reaction to a drug called paclitaxel or similar medicines
• You have taken biologic medications (a type of specialist drug) in the 6 months before screening, or you expect to take them in the next 24 months
• You have taken steroid tablets by mouth in the 30 days before your first study appointment
• You are planning to have a procedure to reduce nerves at the back of the nose in the next 24 months
• You have previously been unable to tolerate a camera examination inside your nose (nasal endoscopy)
• You have another medical condition that could affect how the study team assesses you or that could put your safety at risk, such as severe lung or breathing problems
• You are pregnant or planning to become pregnant during the first 12 months of being in the study
• You have had any nasal or sinus surgery of any kind in the 6 months before your first study appointment
• You have previously had a specific advanced type of frontal sinus surgery called a Draf III procedure, or this type of surgery is expected to be part of your treatment in this study
• Your surgery during the study did not include treatment of both ethmoid and both frontal sinuses as required
• Your planned surgery is expected to include steroid-releasing implants or non-dissolving packing or stents placed in the nose
• Your surgery during the study was stopped or not completed for any reason
• Your life expectancy is less than 2 years

Important: Always verify eligibility with the trial site directly before applying.