Rheumatoid Arthritis Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are at least 18 years old
• People who have been diagnosed with rheumatoid arthritis (RA) according to established 2010 classification guidelines
• People whose RA is at least moderately active, meaning they have 4 or more tender joints, 4 or more swollen joints, and a disease activity score above a certain threshold at the start of the trial
• People with a blood marker of inflammation (hsCRP) above a certain level at a qualifying visit
• People who are on a stable, unchanged dose of any background RA medication (confirm with trial site for specific requirements)
• People who are able and willing to attend all required study visits, daily treatment sessions in the study vehicle, and complete all assessments

Who may not be able to join:

• People who are unable to give informed consent to participate
• People who are currently in, or planning to join, another interventional clinical trial
• People who have an inflammatory joint condition other than RA, such as gout, lupus, psoriatic arthritis, ankylosing spondylitis, or related conditions (note: secondary Sjögren's Syndrome is allowed)
• People who have previously tried more than 2 biologic or targeted RA medications that were stopped mainly because they were not working
• People whose conventional RA medication (such as methotrexate) was started within the last 12 weeks, or had its dose changed or stopped within the last 4 weeks, or cannot be kept at a stable dose during the study
• People whose biologic RA medication was started or had its dose changed within the last 12 weeks, or was stopped within the last 4 weeks, or cannot be kept at a stable dose during the study
• People whose JAK inhibitor medication was started, changed in dose, or stopped within the last 4 weeks, or cannot be kept at a stable dose during the study
• People whose corticosteroid (such as prednisone) was started, changed in dose, or stopped within the last 4 weeks, or who are currently taking more than 10 mg per day of prednisone or an equivalent steroid, or cannot maintain a stable dose during the study
• People who started, changed, or stopped high-dose anti-inflammatory painkillers (NSAIDs at 1200 mg/day ibuprofen or more) within the last 14 days (standard over-the-counter NSAID use is permitted)
• People who are pregnant or planning to become pregnant during the study
• People with a known allergy or sensitivity to ultrasound gel or the membrane materials used in the device
• People with a history of spleen problems, including having had the spleen removed, being born without a spleen, or having an enlarged spleen detected on ultrasound
• People with a rash, wound, or skin infection over the area of the spleen
• People with a history of vagus nerve injury, surgical cutting of the vagus nerve, or a known condition affecting the autonomic nervous system
• People who have had abdominal surgery or an abdominal injury within the last 30 days
• People whose spleen is too deep beneath the skin surface (more than 7 cm) as measured by ultrasound
• People whose abdominal anatomy makes it difficult to target the spleen accurately with ultrasound
• People with uncontrolled fibromyalgia or widespread pain conditions that could make it hard to accurately assess symptoms during the trial
• People who, in the trial doctor's judgment, cannot safely participate or follow the study procedures

Important: Always verify eligibility with the trial site directly before applying.