Sleep Disorders Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged between 23 and 45 years.
• People who are able and willing to sign a written consent form agreeing to take part.
• People who are fluent in Danish and can understand the study's procedures and instructions.
• People who are generally healthy, based on their medical history, health questionnaires, and basic checks such as blood pressure and heart rate.
• People who have had a regular, consistent sleep schedule for at least 4 weeks before the study visit — typically sleeping 6.5 to 9 hours per night, usually going to sleep between around 10:00 pm and 1:00 am and waking between around 6:00 am and 9:00 am.
• People whose body weight falls within a standard healthy range (roughly a BMI of 18.5–30), if the study doctor considers this necessary.
• People who have not done regular night shifts or rotating shift work in the 3 months before joining.
• People who have not travelled across more than 2 time zones in the 2 months before the main study session.
• People who are willing to avoid caffeine, nicotine, alcohol, and recreational drugs for set periods before and during the 36-hour study session.
• People who could become pregnant must have a negative pregnancy test at screening and arrival, and must agree to use reliable contraception throughout their participation.

Who may not be able to join:

• People who have a known or suspected major sleep disorder, such as insomnia, sleep apnoea, restless legs syndrome, or narcolepsy.
• People with a current or past significant psychiatric or neurological condition — such as major depression, bipolar disorder, psychotic disorders, or epilepsy — unless the condition is considered mild and stable and is specifically approved by the study doctor.
• People with ongoing medical conditions that could be made worse by staying awake for a long period, or that could affect the study results — for example, significant heart disease, uncontrolled high blood pressure, diabetes, severe breathing problems, or other serious illness.
• People who regularly take medications or supplements that may affect sleep, body clock rhythms, melatonin, alertness, or mood — such as sleeping tablets, melatonin supplements, stimulants, certain antidepressants, or beta-blockers — unless a safe period of stopping them is possible and approved by the study doctor.
• People with very high daily caffeine intake (for example, more than 400 mg per day) or nicotine dependence, if they are unable or unwilling to stop for the required periods before the study.
• People who currently use alcohol harmfully, have a substance use disorder, or frequently use recreational drugs.
• People who are pregnant or breastfeeding.
• People who have previously had a severe reaction to sleep deprivation, extended wakefulness, or similar study procedures.
• People who experience claustrophobia or who would not be able to tolerate spending an extended period in a controlled laboratory setting.
• People who have any other condition or circumstance that the study investigators consider would make participation unsafe, interfere with the 36-hour wakefulness protocol, or affect the quality of the study data — for example, a strong fear of needles or saliva sampling, or an inability to follow the study's restrictions.

Important: Always verify eligibility with the trial site directly before applying.