Heart Disease Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- People who have been diagnosed with heart failure where the heart's pumping strength is significantly reduced (specifically, the heart pumps out 35% or less of its blood with each beat), with this diagnosis confirmed within the past 12 months
- People whose heart failure symptoms currently fall into a moderate-to-severe category, or who currently have moderate symptoms but previously had more severe symptoms (confirm with trial site if unsure which category applies)
- People whose most recent blood test result for a heart stress marker called NT-proBNP was below 1600 pg/ml, tested within the past 3 months
- People who are already being treated with the maximum heart failure medications and devices that they are able to tolerate
- People aged 18 years or older
Who may not be able to join:
- People under 18 years of age
- People who have had a heart attack, loss of consciousness, stroke, or a life-threatening heart rhythm event (including a shock from an implanted heart device) within the past 3 months
- People whose carotid artery branching points (in the neck) are located higher up than a certain anatomical landmark near the jaw (confirm with trial site)
- People who have a narrowing of more than 50% in a carotid artery (a major neck artery) caused by a build-up of fatty deposits
- People who have irregular, potentially unstable fatty deposits in a carotid artery
- People who have a condition affecting how the body automatically regulates blood pressure, or nerve damage affecting the body's automatic functions
- People who have an uncontrolled slow heart rate that is causing symptoms
- People with severe long-term lung disease
- People currently receiving medications given to make the heart pump harder (inotropes)
- People who have had a pacemaker or implanted heart rhythm device fitted within the past 3 months
- People who have had a cardiac resynchronisation therapy (a specialised heart device) fitted within the past 6 months, or where fitting one is planned within the next 90 days
- People who have previously had surgery, radiation treatment, or a stent placed in a specific area of the carotid artery in the neck
- People who have had, or are being considered for, an organ transplant
- People who have had, or are being considered for, a mechanical heart assist device implanted in the left side of the heart
- People whose life expectancy is estimated to be less than 1 year at the time of screening
- People who have a condition unrelated to the heart that would prevent them from completing a walking test used in this trial
- People who are unable to meet the requirements of the trial for any reason
- People with a known allergy to silicone or titanium
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Nir Uriel, MD, Columbia University
Phone: 914-629-3121
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Change in peak exercise PCWP at 6 months post-titration
Can't join this trial?
Data last synced from ClinicalTrials.gov: 27 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.