Phase 2 Liver Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are between 18 and 75 years old
• You have been diagnosed with liver cancer (hepatocellular carcinoma) confirmed by a tissue or cell sample, and you have not received any treatment for it before surgery (such as chemotherapy, targeted therapy, immunotherapy, radiation, or other procedures)
• You had surgery to remove the liver cancer within the past 8 weeks, the surgeon removed all visible cancer with clear margins, and a scan taken at least 4 weeks after surgery confirmed no remaining signs of cancer
• Your general health and ability to carry out daily activities is rated as fully active or restricted only in physically demanding activity (confirm with trial site)
• You have at least one feature that puts you at higher risk of the cancer coming back, such as: a single tumor larger than 5 cm, cancer that has spread into nearby blood vessels, three or more tumors, an aggressive tumor type, or surgery margins of 1 cm or less
• If your AFP blood marker (a liver cancer indicator) was high before surgery, it must have dropped significantly after surgery and not be rising again
• If you have Hepatitis B or C, you must already be receiving standard antiviral treatment and be willing to continue it throughout the study
• Your blood, liver, kidney, and clotting test results are within acceptable ranges as confirmed by your doctor
• Your life expectancy is more than 12 months
• You are not pregnant

Who may not be able to join:

• Scans after surgery show that the cancer has spread outside the liver, or there are remaining or returning tumors
• You have already received additional treatments such as chemoembolization (TACE) after your surgery
• Your liver function is rated as grade B or C on the Child-Pugh scale, or you have a history of a condition called hepatic encephalopathy (brain problems caused by liver disease)
• You have a significant fluid build-up around your heart, or you need fluid drained from around your lungs or abdomen
• You have had a bleeding episode (such as from swollen veins in the food pipe or stomach) in the past 6 months, have untreated swollen veins considered high-risk for bleeding, or needed treatment for such veins in the past 28 days
• You are unable to have contrast-enhanced CT or MRI scans of your liver
• Your surgery did not fully meet the requirements for complete cancer removal
• You have taken certain Chinese herbal medicines, traditional patent medicines, or immune-boosting drugs (such as thymosin or interferon) within the past 14 days
• You have taken part in another drug clinical trial within the past 4 weeks
• You have both Hepatitis B and active Hepatitis C at the same time
• You have had a serious blood clot or cardiovascular event in the past 6 months, such as a heart attack, stroke, blood clot in the lungs, or deep vein thrombosis
• You have significant heart or lung problems
• You have a serious active infection, or had a severe infection (such as one requiring hospitalisation) within the past 4 weeks
• You have a known allergy to any ingredient in the study drug, or a history of severe allergic reactions to traditional Chinese medicines
• You have a known history of drug or alcohol misuse
• You have a psychiatric condition that affects your ability to make decisions or give informed consent
• You have any other serious health condition or abnormal test results that your doctor believes would make participation unsafe or unsuitable

Important: Always verify eligibility with the trial site directly before applying.