Phase 4 Heart Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged between 40 and 85 years old
• People who were hospitalised in the past 30 to 90 days for a documented acute coronary syndrome (a serious heart event such as a heart attack or unstable chest pain)
• People who, during that hospitalisation, had either a procedure to open a blocked artery (called PCI) or a diagnostic procedure to look at the heart's arteries (coronary angiography)
• People who have at least one artery with a partial blockage of 30–70% that was not the main cause of the heart event, as seen on the artery imaging
• People who have been medically stable throughout the screening period leading up to the trial
• People who are receiving the standard recommended treatment for their heart condition according to national guidelines
• People who have had a blood sample taken for DNA testing, with results showing either a specific genetic finding called TET2-CHIP, or no CHIP-related genetic changes at all (confirm with trial site)
• People who are able and willing to provide written consent to participate

Who may not be able to join:

• People who had open-heart bypass surgery (CABG) before their recent heart event
• People with other significant heart conditions, including moderate-to-severe heart valve disease, severe heart failure (NYHA class III or IV), or atrial fibrillation
• People whose artery anatomy makes it unsuitable for a specialised heart CT scan to assess plaque (confirm with trial site)
• People who have a bypass surgery or artery-opening procedure already planned
• People with significantly abnormal liver function at the time of enrolment
• People with significantly abnormal kidney function at the time of enrolment
• People with certain blood abnormalities at the time of enrolment, including low red blood cells (anaemia), low platelets, or low white blood cells
• People with inflammatory bowel disease (such as Crohn's disease or ulcerative colitis) or active diarrhoea
• People with nerve or muscle conditions, including symptomatic nerve damage, a progressive neuromuscular disease, or a significantly elevated muscle enzyme level that has been confirmed as ongoing
• People who are pregnant, breastfeeding, or who could become pregnant and are not using an effective form of contraception
• People who have a known allergy, intolerance, or other medical reason they cannot take colchicine
• People who have used colchicine in the 30 days before enrolment, or who plan to take it for another condition
• People who are currently taking or plan to take certain medications that interact with colchicine, including cyclosporine, verapamil, certain HIV medications, azole antifungal medicines, or macrolide antibiotics
• People who are currently using or plan to use other anti-inflammatory or immune-suppressing medications
• People with a history of any cancer, whether blood-related or a solid tumour
• People who have had an organ transplant or a stem cell transplant
• People who have had significant radiation exposure within the past 12 months
• People with a known allergy to the contrast dye used in CT or X-ray imaging, or who have an uncontrolled overactive thyroid
• People who are currently enrolled in another clinical trial
• People whose life expectancy is estimated to be less than one year
• People the trial investigator considers unsuitable for participation for any other reason

Important: Always verify eligibility with the trial site directly before applying.