Liver Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults aged 18 or older
• People who are able to give written consent to participate
• People who have been diagnosed with colorectal adenocarcinoma (a specific type of bowel cancer), confirmed through tissue testing
• People who are scheduled for surgery or ablation (a procedure to destroy tumour tissue) on the liver at Rigshospital, or who are receiving cancer treatment for colorectal cancer that has spread to the liver at Zealand University Hospital
• People who have at least one liver metastasis (area where cancer has spread) that can be assessed using a special ultrasound scan called CEUS
• People with a general health and activity level rated 0–2 on a standard medical scale (meaning able to carry out at least some daily activities, with or without some limitations)
• Women who could become pregnant must use highly effective contraception throughout the trial period, as specified in official clinical trial guidelines; pregnancy testing may be required if there is any uncertainty

Who may not be able to join:

• People who have received systemic cancer treatment (treatment that travels through the whole body) within 2 weeks before joining the trial
• People who have previously been treated with a type of cancer immunotherapy called an immune checkpoint inhibitor (for example, anti-PD-1 or anti-PD-L1 drugs)
• People whose liver metastasis cannot be clearly identified and separated from other liver spots using the CEUS ultrasound scan
• People who have taken high-dose corticosteroids (more than 10 mg of prednisolone or equivalent per day) or other medications that suppress the immune system within 2 weeks before joining — note that inhaled or topical steroids, and low-dose replacement steroids, may be permitted if there is no active autoimmune disease (confirm with trial site)
• People with a known history of HIV, or active or ongoing hepatitis B or C infection
• People who are pregnant or breastfeeding
• People whose bowel cancer tumour has tested positive for a specific genetic marker called dMMR
• People who are unable to follow the study procedures due to psychological, social, or practical reasons
• People with a known allergic reaction to SonoVue® or any other ultrasound contrast agent used in CEUS scans
• People with uncontrolled high blood pressure in the arteries
• People with a known hole or abnormal opening between the right and left sides of the heart (right-to-left intracardiac shunt)
• People with severe high blood pressure in the lungs (pulmonary hypertension with pressure above 90 mmHg)
• People with a serious condition causing fluid in the lungs known as adult respiratory distress syndrome
• People with a known allergy to macrogols (a type of compound found in some medications)
• People with unstable heart disease or a recent or ongoing heart attack
• People with severe lung disease, such as severe chronic obstructive pulmonary disease (COPD)

Important: Always verify eligibility with the trial site directly before applying.