Depression and Anxiety Trial, By Invitation
voxsanity.com.au · Eligibility summary from public government registries · 18 August 2026 · not medical advice
Who may and may not be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who may be able to join
- People aged 22 to 85 years, male or female.
- People who have been diagnosed with major depressive disorder (a serious form of depression) by a psychiatrist, without psychotic features, based on recognised diagnostic guidelines (DSM-5).
- People whose depression has not improved despite trying antidepressant medication at an adequate dose, for an adequate length of time, and taken as directed.
- People with a depression severity score above 20 on a standard rating scale (called the MADRS), both at the start of the study and just before the treatment day.
- People who are willing and able to follow the study's treatment schedule and attend all follow-up appointments.
- People whose antidepressant medications and any psychotherapy have remained unchanged for at least 4 weeks before joining, and who agree not to request changes to these until at least 2 weeks after the study treatment is completed.
- People who are fluent in English.
Who may not be able to join
Each point below is a reason the trial team may not be able to accept someone. It is not a list of requirements to meet.
- People with medical conditions that would make it unsafe to receive a brain stimulation treatment called rTMS (confirm with trial site).
- People with conditions that prevent them from having an MRI scan.
- People who are pregnant, as confirmed by a blood or urine test.
- People with a history of epilepsy, seizures, or a seizure disorder, as assessed by the principal investigator.
- People who are currently misusing alcohol or drugs.
- People who have a diagnosis of bipolar disorder or a psychotic disorder.
- People considered to be at moderate to high risk of suicide, based on a standard safety assessment called the C-SSRS.
- People who have cognitive impairment (difficulties with memory or thinking), as determined by the principal investigator based on medical history or the results of a standard screening test called the MoCA.
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
If you need support right now
This page includes language about suicide and self-harm, because that is how the trial's eligibility criteria are written. If reading it has been hard, you do not have to keep going. The services below are free, confidential, and answered by people trained for exactly this.
If you or someone else is in immediate danger, call 000.
- Lifeline — 24/7 crisis support: 13 11 14
- Suicide Call Back Service — 24/7 counselling: 1300 659 467
- 13YARN — 24/7, for Aboriginal and Torres Strait Islander people: 13 92 76
- Beyond Blue — 24/7 mental health support: 1300 22 4636
- Emergency: 000
Outside Australia? The numbers above are Australian and will not work from overseas. Find a Helpline is a free directory of crisis lines in over 130 countries, run by ThroughLine with the International Association for Suicide Prevention. If you are in immediate danger, call your local emergency number.
Voxsanity is not a crisis service, and nothing on this page is medical advice. More Australian services are listed on our support lines page.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
This date has passed while the registry still lists the trial as open to participants. Sponsors often update a trial's status without revising its projected end date, so it may well still be recruiting — but the record is out of date in at least one respect. Check with the study contact before relying on either.
Where this trial is recruiting
Primary endpoints
MADRS Score
Can't join this trial?
Data last synced from ClinicalTrials.gov: 16 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.