Heart Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are seeking emergency treatment, including those presenting to an emergency room
• People who have been diagnosed with paroxysmal atrial fibrillation (a type of irregular heartbeat that starts and stops on its own) according to current medical guidelines
• People who have been diagnosed with a specific type of heart failure called HFpEF, where the heart pumps normally but does not relax properly, confirmed by certain symptoms, heart scans, and blood test results at levels specified in the guidelines
• People aged between 18 and 80 years
• People whose left atrial chamber of the heart measures less than 55mm in size
• People whose heart pumping function (ejection fraction) is greater than 50%
• People who are able to give informed consent and are willing to attend all required study visits and follow-up appointments

Who may not be able to join:

• People who are currently taking part in another interventional clinical trial involving a drug, device, or biological treatment
• People with any illness that is expected to limit life expectancy to less than one year
• People who have a medical reason that makes a pulmonary vein isolation procedure (a heart procedure) unsuitable for them
• People who have a medical reason that makes anti-arrhythmic drug therapy (medication to control heart rhythm) unsuitable for them
• People who have an active infection affecting the whole body
• People with abnormally high or low platelet counts in their blood
• People with a known pre-existing paralysis of one side of the diaphragm (the muscle used for breathing)
• People with an untreated or uncontrolled overactive or underactive thyroid gland
• People whose immune system is weakened or who are considered by their doctor to be at high risk of infection
• People with a currently active cancer, or who have previously received chemotherapy or radiation treatment
• People who have previously had a left atrial ablation procedure or any surgical procedure on the left side of the heart, including left atrial appendage closure
• People who have had heart surgery, a heart attack, or a procedure to open or stent a coronary artery within the 3 months before eligibility is assessed
• People with unstable angina (chest pain that is unpredictable or occurs at rest)
• People with primary pulmonary hypertension (high blood pressure in the lungs not caused by another condition)
• People who have a medical reason that makes long-term blood-thinning medication unsuitable for them
• People who have had a stroke or mini-stroke (TIA) within the 3 months before the consent date
• People who have an artificial heart valve
• People whose left atrial chamber measures more than 55mm on an ultrasound of the heart
• People who have pulmonary vein stents already in place
• People who have a significant narrowing (70% or more) of any pulmonary vein, identified by CT or MRI scan
• People with an infection or inflammation of the heart lining or surrounding sac, or fluid around the heart
• People who are pregnant, breastfeeding, or of childbearing potential and not using adequate contraception
• People with a current substance abuse problem
• People who are unwilling to follow the study protocol or attend follow-up visits

Important: Always verify eligibility with the trial site directly before applying.