Phase 2 Liver Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with advanced colorectal cancer (a type of bowel cancer) confirmed by laboratory testing of tissue or cell samples.
• People whose cancer has spread to areas other than the liver, and who have clearly decided they do not want chemotherapy.
• People who have not had any previous systemic (whole-body) cancer treatment, or whose cancer came back or spread more than 12 months after finishing an earlier course of preventive (adjuvant) treatment.
• People who have at least one tumour that can be measured according to standard imaging guidelines (called RECIST 1.1).
• People who have had radiotherapy to another area in the past, as long as it was completed at least 3 weeks before joining the trial and the treated area is not being used to measure the cancer's response.
• People aged 18 or older.
• People who are generally well enough to carry out daily activities, with a fitness score of 0 or 1 on a standard medical scale (confirm with trial site).
• People who are expected to live for at least 12 weeks.
• People who are able to understand the study and are willing to sign a consent form.
• Women who could potentially become pregnant must have a negative pregnancy test within 7 days before starting treatment, and both the patient and their partner must agree to use reliable contraception throughout the study.

Who may not be able to join:

• People who have had major surgery or a serious injury within the 4 weeks before starting the trial.
• People who have previously had a serious allergic reaction to any medicine used in this trial.
• People who are pregnant or are planning to become pregnant.
• People whose cancer has spread to the brain and who are unable to clearly describe their own symptoms or condition.
• People who have a history of autoimmune diseases (conditions where the immune system attacks the body) or who have had an organ transplant.
• People who have taken medicines that suppress the immune system within the 2 weeks before starting the trial (not including low-dose steroid inhalers or very low daily steroid doses).
• People who have received a live vaccine within 4 weeks before starting the trial, or who plan to receive one during the study.
• People who have previously been treated with certain targeted or immunotherapy medicines, including anlotinib or drugs that work on immune checkpoint pathways (confirm with trial site).
• People who have had a heart attack, severe chest pain, significant heart failure, or poorly controlled irregular heartbeat within the 6 months before starting the trial.
• People whose recent blood or organ function test results fall outside acceptable ranges, including low white blood cell counts, low platelet counts, or reduced liver or kidney function (confirm specific values with trial site).
• People who have been diagnosed with another cancer within the past 5 years, except for certain early-stage or previously cured cancers such as early cervical changes, treated skin cancer, or certain bladder conditions.
• People whose colorectal cancer could be removed by surgery with the aim of a cure — though people who have clearly refused surgery, or who a doctor has determined are not suitable for surgery, may still be considered eligible.
• People with a history of substance abuse or alcohol dependence.
• People who do not have the legal capacity to make their own decisions.
• People who the trial doctor believes are not suitable for the trial for any other reason.

Important: Always verify eligibility with the trial site directly before applying.