Phase 2 Rheumatoid Arthritis Trial, Recruiting NCT07423533 Sponsor: Changchun GeneScience Pharmaceutical Co., Ltd. Condition: Rheumatoid Arthritis
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Phase 2 Rheumatoid Arthritis Trial, Recruiting

NCT07423533
Recruiting Phase 2

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • People who are willing to give their written agreement to take part, understand what the study involves, and commit to following the study procedures throughout.
  • People aged 18 to 70 years (inclusive) at the time of signing the consent form.
  • People who have been diagnosed with rheumatoid arthritis (RA) according to recognised international classification guidelines, with a functional level rated as Class I, II, or III (meaning some ability to carry out daily activities is still present) (confirm with trial site).
  • People whose RA is moderately to severely active, based on specific counts of tender and swollen joints (at least 6 of each) and elevated inflammation markers in blood tests at the time of screening and at the start of the study.

Who may not be able to join:

  • People with a known allergy to any ingredient in the study drug (GenSci120), or who have a history of allergic reactions to any medications, substances, or foods.
  • People who have another autoimmune or autoinflammatory condition in addition to RA — such as psoriatic arthritis, lupus, inflammatory bowel disease, ankylosing spondylitis, multiple sclerosis, or primary Sjögren's syndrome, among others (secondary Sjögren's syndrome is excluded from this restriction — confirm with trial site).
  • People who have another joint condition, such as severe osteoarthritis, that could make it difficult to accurately assess RA disease activity, as determined by the study doctors.
  • People who have a history of lymphoma or other disorders affecting the lymph system, or who currently show signs such as abnormally enlarged lymph nodes or an enlarged liver or spleen.
  • People who currently have, or have previously had, a cancer diagnosis.

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 28 July 2026
Phase 2: approximately ~30% of drugs entering this phase reach regulatory approval, based on published industry-wide historical data. This is not specific to this trial.
Phase success rates shown are historical industry-wide averages based on published data. They are not a prediction for this specific trial or your individual situation.

Contact this trial

Principal Investigator: Zhanguo LI, Doctor, Peking University People's Hospital

Phone: +86 18201085833

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Phase 2
Sponsor
Changchun GeneScience Pharmaceutical Co., Ltd.
Registry
ClinicalTrials.gov
Start date
30 April 2026
Est. completion
1 September 2027

Where this trial is recruiting

🇨🇳 China

Primary endpoints

Proportion of participants achieving the American College of Rheumatology 20% improvement criteria (ACR20) for disease activity assessment in RA from baseline after 14 weeks of administration

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 28 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov