Phase 2 Chronic Rhinosinusitis Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are between 18 and 55 years old (for healthy volunteers) or between 18 and 75 years old (for patients), and weigh no more than 120 kg
• Your Body Mass Index (BMI — a measure based on height and weight) is between 18 and 30
• If you are a woman who could become pregnant, you must have a negative pregnancy test
• You are willing to avoid drinking alcohol for 24 hours before each study visit
• You are a non-smoker, an ex-smoker, or someone who smokes no more than 5 cigarettes per day

For one part of the trial (Part B) only, you must also:

• Have been diagnosed by a doctor with chronic sinusitis with nasal polyps for at least 12 months before joining
• Have a symptom score of 30 or above on a standard sinus symptom questionnaire at two separate check-ins
• Have used steroid tablets or injections in the past 24 months, or have a medical reason why you cannot take them
• Have been diagnosed with asthma (confirm with trial site), with your condition stable and on a certain level of asthma treatment for at least 6 weeks before the trial

Who may not be able to join:

• You have tested positive for HIV, hepatitis B, or hepatitis C
• You have a weakened immune system, an autoimmune disease, or a history of cancer, or conditions that make infections more likely
• You have a history of serious problems affecting your metabolism, skin, liver, kidneys, or blood
• Your blood test results show abnormal levels, such as low blood counts, abnormal liver or kidney function
• You test positive for drugs or alcohol, or have abnormal blood pressure, heart rate, or other vital signs at check-in
• Your heart tracing (ECG) shows abnormal results
• You have had problems with drug or alcohol misuse in the past 2 years
• You have a history of severe allergic reactions

For Part B of the trial only, you may also not be able to join if:

• You have had surgery on your sinuses or nose (including removal of polyps) within the last 6 months, or have had 2 or more such surgeries in the past
• You have another nasal or sinus condition that could affect the study results (confirm with trial site)
• You have a serious or unstable heart or cardiovascular condition
• You have had a significant infection recently (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.