Phase 1 Sleep Disorders Trial, Recruiting (NCT07444580)

Phase 1 Sleep Disorders Trial, Recruiting NCT07444580 Sponsor: Broad Institute of MIT and Harvard Condition: Sleep Disorders

Printed from Voxsanity (voxsanity.com.au) — NCT07444580 — Data sourced from ClinicalTrials.gov. Verify directly with the trial site before attending. Not medical advice.

Back to Sleep Disorders

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

You are showing clinical signs and symptoms that a doctor believes are consistent with prion disease
You have been diagnosed with "probable prion disease" based on specific recognised medical guidelines (CDC criteria)
You have had a positive result from either a spinal fluid test (called RT-QuIC) or a genetic test related to the prion protein gene (PRNP)
Your ability to carry out daily activities is not severely affected, based on a specific scoring scale used for prion disease (confirm with trial site)
You have someone (such as a family member or carer) who is able to help you take part in the study procedures

Who may not be able to join:

You are currently pregnant
You are unable to have a lumbar puncture (spinal tap) for any reason, such as a medical condition that makes it unsafe
You have recently taken part in a different clinical trial for prion disease

Important: This list does not cover all eligibility requirements — additional criteria will be checked during a screening appointment. Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.

Last synced 7 July 2026

Phase 1: approximately ~10% of drugs entering this phase reach regulatory approval, based on published industry-wide historical data. This is not specific to this trial.

Phase success rates shown are historical industry-wide averages based on published data. They are not a prediction for this specific trial or your individual situation.

Contact this trial

Principal Investigator: Eric V Minikel, PhD, Broad Institute of MIT and Harvard

Phone: 617 714 7000

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Voxsanity

Clinical trials and treatments, explained plainly · voxsanity.com.au

Date:

To: My Doctor

Re: Clinical trial enquiry

I am writing to enquire about the following clinical trial which may be relevant to my care:

Trial: NCT07444580

Sponsor: Broad Institute of MIT and Harvard

Phase: Phase 1

Status: Recruiting

Condition: Sleep Disorders

Trial contact: 617 714 7000

More information: https://clinicaltrials.gov/study/NCT07444580

Eligibility summary (AI generated)

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

You are showing clinical signs and symptoms that a doctor believes are consistent with prion disease
You have been diagnosed with "probable prion disease" based on specific recognised medical guidelines (CDC criteria)
You have had a positive result from either a spinal fluid test (called RT-QuIC) or a genetic test related to the prion protein gene (PRNP)
Your ability to carry out daily activities is not severely affected, based on a specific scoring scale used for prion disease (confirm with trial site)
You have someone (such as a family member or carer) who is able to help you take part in the study procedures

Who may not be able to join:

You are currently pregnant
You are unable to have a lumbar puncture (spinal tap) for any reason, such as a medical condition that makes it unsafe
You have recently taken part in a different clinical trial for prion disease

Access in Australia: A treatment being studied in a clinical trial is generally not yet listed on the PBS. Where a medicine is not approved or not available through a trial, the TGA Special Access Scheme may allow a doctor to access unapproved therapeutic goods for individual patients. See voxsanity.com.au/sas-navigator/ for a plain English explainer.

This information was sourced from ClinicalTrials.gov via Voxsanity (data last synced 7 July 2026). It is not medical advice. Please verify the trial's current status directly with the trial site before acting.

Trial details

Status

Recruiting

Phase

Phase 1

Sponsor

Broad Institute of MIT and Harvard

Registry

ClinicalTrials.gov

Start date

15 May 2026

Est. completion

14 August 2029

Where this trial is recruiting

🇺🇸 United States

Primary endpoints

Frequency of adverse events

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 7 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov