Printed from Voxsanity (voxsanity.com.au) — NCT07466927 — Data sourced from ClinicalTrials.gov. Verify directly with the trial site before attending. Not medical advice.
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Phase 2 Breast Cancer Trial, Not Yet Recruiting
NCT07466927
voxsanity.com.au · Eligibility summary from public government registries · 18 August 2026 · not medical advice
Who may and may not be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who may be able to join
- Women aged 18 or older.
- People diagnosed with invasive breast cancer that has been confirmed by a tissue sample (biopsy) and is HER2-negative (meaning the cancer tests negative for a specific protein called HER2).
- People whose breast cancer has spread to the liver.
- People whose cancer has come back or spread, and who have already tried at least one standard treatment that stopped working — for hormone receptor-positive (HR+) breast cancer, this includes having previously received a specific type of targeted therapy called a CDK4/6 inhibitor; for hormone receptor-negative (HR-) breast cancer, this includes having received at least one round of chemotherapy.
- People who have at least one area of cancer that can be measured on a scan (not in an area that has already been treated with radiation), separate from any liver lesions being targeted in this trial.
- People whose liver metastases meet specific size and number limits: no more than 10 spots in the liver, each no larger than 4 cm, and none involving nearby blood vessels or bile ducts.
- People whose blood test results show that their blood counts and liver function are within the ranges required by the trial (confirm specific values with the trial site).
- People who are expected to live for at least 12 weeks.
- Women who are able to become pregnant must be willing to use an approved method of contraception throughout the study treatment period and for at least 3 months after the last dose.
- People who have agreed to take part voluntarily, signed a consent form, and are willing to attend follow-up appointments as required.
Who may not be able to join
Each point below is a reason the trial team may not be able to accept someone. It is not a list of requirements to meet.
- People who have cancer that has spread to the brain or nervous system and is causing symptoms, or requires steroids or other medications to control those symptoms.
- People with a significant history of heart problems, including heart failure, chest pain (angina), a heart attack in the past 6 months, or serious irregular heartbeats.
- People who have had radiotherapy or surgery for their breast cancer within 1 week before starting the trial.
- People who are pregnant or currently breastfeeding.
- People who have been diagnosed with another cancer in the past 3 years, except for certain treated skin cancers or early-stage cervical changes that have been fully treated.
- People with serious other health conditions, including mental health conditions that, in the opinion of the trial doctor, could interfere with participation.
- People with a history of bleeding in the digestive system (such as the stomach or oesophagus) in the past 6 months, or signs of a significant risk of such bleeding (confirm specific details with the trial site).
- People who have had a hole or tear in the digestive tract, or an infection inside the abdomen, within 28 days before joining the trial.
- People whose urine tests show a high level of protein, or whose 24-hour urine collection shows more than a certain amount of protein (confirm with trial site).
- People with high blood pressure that cannot be brought under control with medication (above 140/90 mmHg).
- People with known allergies to any of the study drugs or to similar types of medications called monoclonal antibodies.
- People with existing thyroid problems.
- People whom the trial doctor considers unsuitable for any other reason.
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Contact this trial
Phone: 86-021-64175590
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Status
Not Yet Recruiting
Phase
Phase 2
Sponsor
Registry
ClinicalTrials.gov
Start date
15 March 2026
Est. completion
15 January 2028
Where this trial is recruiting
🇨🇳 China
Primary endpoints
Progression Free Survival (PFS)
Can't join this trial?
Data last synced from ClinicalTrials.gov: 31 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.
Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.