Phase 1 Liver Cancer Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 18 or older
• People who have been diagnosed with advanced liver cancer (hepatocellular carcinoma), confirmed by tissue testing, cell testing, or medical assessment
• People whose liver cancer has been staged as Barcelona stage B or C (a system doctors use to assess how far the cancer has progressed)
• People who have not yet received any systemic (whole-body) treatment for their liver cancer
• People who have at least one tumour that can be measured using standard imaging guidelines
• People whose liver function scores fall within a certain range (Child-Pugh score A or B7 — confirm with trial site)
• People with a physical functioning score of 0 or 1 on the ECOG scale, meaning they are fully active or have only minor limitations in daily activities
• People whose doctors estimate they are likely to live for at least 12 weeks
• People whose major organs (such as heart, kidneys, and bone marrow) are functioning adequately
• People who have signed the trial's consent form

Who may not be able to join:

• People whose tissue or cell testing confirms certain less common types of liver or bile duct cancers, including mixed liver-bile duct cancer, sarcomatoid liver cancer, or fibrolamellar liver cancer
• People who have had, or currently have, another active cancer (other than liver cancer) within the past 5 years — though some fully treated localised cancers (such as certain skin, bladder, prostate, cervical, or breast cancers) may still be eligible (confirm with trial site)
• People who have previously received an organ transplant from another person, such as a liver transplant
• People whose liver tumours currently make up more than 50% of the total liver volume
• People who experienced significant bleeding (grade 3 or above) within the past 6 months, or moderate non-gastrointestinal bleeding (grade 2) within the past 3 months
• People who had an abdominal fistula, a hole in the gastrointestinal tract, or an abdominal abscess within the past 6 months
• People who had a major blood vessel problem within the past 6 months
• People who currently have, or have previously needed hormone treatment for, a lung condition involving scarring or inflammation of lung tissue (interstitial lung disease)
• People with a weakened immune system, whether from birth or due to a condition such as HIV infection
• People who had a serious infection within the 28 days before starting the trial

Important: Always verify eligibility with the trial site directly before applying.