Printed from Voxsanity (voxsanity.com.au) — NCT07589972 — Data sourced from ClinicalTrials.gov. Verify directly with the trial site before attending. Not medical advice.
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Breast Cancer Trial, Not Yet Recruiting
NCT07589972
voxsanity.com.au · Eligibility summary from public government registries · 18 August 2026 · not medical advice
Who may and may not be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who may be able to join
- People who are willing to take part in the study and sign a consent form agreeing to participate.
- People who are aged 70 or older at the time of signing the consent form.
- People who are generally able to carry out daily activities with little or no limitation, and who are expected to live for more than 3 months (confirm with trial site).
- People who have been confirmed by tissue or cell testing to have HER2-positive breast cancer in the original tumour site.
- People whose primary breast tumour is larger than 2 cm, or who have cancer that has spread to the lymph nodes under the arm.
- People whose blood test results meet specific required levels for immune cells, platelets, red blood cells, liver function, kidney function, and other markers — the trial site will check these in detail.
- People whose blood clotting test results are within the required range, and who are not on blood-thinning medication (confirm with trial site).
- People whose urine protein levels are within acceptable limits as tested at screening.
- People whose thyroid hormone levels and heart pumping function (measured by a scan) meet the required thresholds.
Who may not be able to join
Each point below is a reason the trial team may not be able to accept someone. It is not a list of requirements to meet.
- People whose breast cancer has spread to other parts of the body (Stage IV), or whose cancer is not able to be removed by surgery after pre-surgery treatment, as assessed by the medical team.
- People who have previously received chemotherapy, hormone therapy, anti-HER2 treatments, or breast surgery for their cancer (excluding a diagnostic biopsy of the primary breast cancer).
- People who have been diagnosed with another cancer within the past 3 years, or who currently have another cancer — though some exceptions may apply for certain cancers that were fully treated by surgery with no recurrence for 5 years, or for specific low-risk cancers such as cervical carcinoma in situ or non-melanoma skin cancer (confirm with trial site).
- People who have had major surgery, a surgical biopsy (other than a diagnostic biopsy of the primary breast cancer), or a serious injury within 28 days before starting study treatment.
- People who have wounds or fractures that have not healed.
- People with a history of uncontrolled use of substances affecting the mind, or uncontrolled psychiatric conditions.
- People with uncontrolled high blood pressure (above certain levels even after treatment) or a history of hypertensive crisis or hypertensive brain complications.
- People with confirmed heart failure or significantly reduced heart pumping function.
- People with certain levels of heart-related conditions such as reduced blood flow to the heart, a previous heart attack, abnormal heart rhythm, or moderate-to-severe heart failure.
- People with chest pain (angina) that requires ongoing medication to manage.
- People with serious lung problems, active lung disease, or a severe active infection that is not under control.
- People who are allergic to any ingredient in the study drugs being tested.
- People whose other health conditions may put their safety at risk or affect their ability to complete the study, as determined by the medical team.
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
This study is not part of the standard drug-approval phase pathway (for example an observational, device, behavioural, or registry study), so a phase success rate does not apply.
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Trial details
Status
Not Yet Recruiting
Phase
Not Applicable
Registry
ClinicalTrials.gov
Start date
20 April 2026
Est. completion
31 December 2027
Primary endpoints
Total pathological complete response (tpCR)
Can't join this trial?
Data last synced from ClinicalTrials.gov: 27 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.
Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.