Phase 2 Depression and Anxiety Trial, Not Yet Recruiting
voxsanity.com.au · Eligibility summary from public government registries · 18 August 2026 · not medical advice
Who may and may not be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who may be able to join
- People who are able to safely receive TMS (a type of brain stimulation) and the study medications being used in the trial
- People who have been on a stable medication routine for at least one month before the study and are able to stay on that same routine throughout the study
- People who are not currently receiving TMS, ECT (electroconvulsive therapy), or ketamine treatment
- People who do not have any active concerns related to suicidal thoughts or behaviours
Who may not be able to join
Each point below is a reason the trial team may not be able to accept someone. It is not a list of requirements to meet.
- People with a history of seizures or epilepsy
- People with a history of any condition, injury, or disease affecting the inside of the brain (confirm with trial site)
- People with a history of traumatic brain injury, including any loss of consciousness lasting more than 15 minutes
- People showing signs of increased pressure inside the skull
- People with any major neurological condition, such as a recent stroke, brain tumour, or a condition causing progressive decline in brain function
- People with serious medical conditions that could become a medical emergency if a seizure were to occur, such as heart abnormalities, irregular heart rhythms, or asthma
- People with severe migraines that may make it difficult to tolerate the treatment
- People who are unable to tolerate an MRI scan
- People who are pregnant
- People with a known allergic reaction to either d-cycloserine or dextromethorphan
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
If you need support right now
This page includes language about suicide and self-harm, because that is how the trial's eligibility criteria are written. If reading it has been hard, you do not have to keep going. The services below are free, confidential, and answered by people trained for exactly this.
If you or someone else is in immediate danger, call 000.
- Lifeline — 24/7 crisis support: 13 11 14
- Suicide Call Back Service — 24/7 counselling: 1300 659 467
- 13YARN — 24/7, for Aboriginal and Torres Strait Islander people: 13 92 76
- Beyond Blue — 24/7 mental health support: 1300 22 4636
- Emergency: 000
Outside Australia? The numbers above are Australian and will not work from overseas. Find a Helpline is a free directory of crisis lines in over 130 countries, run by ThroughLine with the International Association for Suicide Prevention. If you are in immediate danger, call your local emergency number.
Voxsanity is not a crisis service, and nothing on this page is medical advice. More Australian services are listed on our support lines page.
Contact this trial
Principal Investigator: Joshua C Brown, MD, PhD, Mclean Hospital
Phone: 617-855-2944
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
P30 TMS-Evoked Potential (TEP) Amplitude
Can't join this trial?
Data last synced from ClinicalTrials.gov: 23 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.