Sleep Disorders Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

For people with obstructive sleep apnea (OSA):

• Adults between 18 and 65 years of age
• People with moderate or severe sleep apnea, confirmed by an overnight sleep study showing 15 or more breathing interruptions per hour
• People who are willing and able to sign a consent form agreeing to take part
• People who are willing to have blood samples taken at multiple points during the study
• People who are willing to use a breathing device (such as a CPAP machine) and accept being randomly assigned to start treatment either straight away or after a delay

For people joining as healthy comparison participants (controls):

• Adults between 18 and 65 years of age
• People with no sleep apnea, confirmed by an overnight sleep study showing fewer than 5 breathing interruptions per hour
• People who are willing and able to sign a consent form agreeing to take part
• People who are willing to have blood samples taken and complete study assessments

Who may not be able to join:

• People with mild sleep apnea (between 5 and fewer than 15 breathing interruptions per hour on a sleep study)
• People whose breathing interruptions during sleep originate from the brain rather than a physical airway blockage (known as central sleep apnea)
• People who have received treatment for sleep apnea in the past 3 months
• People with a body mass index (BMI) of 40 or above (a measure of body weight relative to height)
• People with serious heart or blood vessel disease
• People with serious kidney disease or significantly reduced kidney function
• People with significant liver disease
• People with ongoing conditions affecting the immune system, such as autoimmune or rheumatic diseases, or other long-term inflammatory conditions
• People with active cancer or any other condition known to cause widespread inflammation in the body
• People with long-term lung or breathing conditions, such as asthma or chronic obstructive pulmonary disease (COPD)
• People who have had a respiratory infection (such as a cold or chest infection) within the 4 weeks before enrolling
• People who have had major surgery or a significant injury within the past 3 months
• People with a long-term condition causing blocked or inflamed sinuses (chronic rhinosinusitis)
• People currently taking steroid tablets, medicines that suppress the immune system, chemotherapy-type drugs, long-term anti-inflammatory medications, or other medicines that may affect inflammation markers in the blood
• People who are pregnant, or who have any other condition that the trial doctors consider would make participation unsafe or affect the study results (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.