Rare disease

Autosomal Dominant Polycystic Kidney Disease

Clinical trials recruiting in Australia for Autosomal Dominant Polycystic Kidney Disease, a rare disease, as the public registries list them.

Also called: ADPKD; PKD; Polycystic kidney disease; Polycystic renal disease

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Sources: ClinicalTrials.gov, MedlinePlus, Orphanet Checked: 13 October 2026 Not medical advice

At a glance

4 trials recruiting in Australia

38 trials recruiting overseas

1-5 / 10 000 (Point prevalence, Europe, Validated) prevalence

Adolescent; Adult; Childhood age of onset

13 October 2026 date last checked

Trials in Australia

This Australian count is likely to be on the low side. It counts the trials this site files under this condition; the registry’s own search is broader and also returns closely related conditions, some of which have their own page here. If you are searching widely, check the registry as well — every trial below links to its own record.

Recruiting Phase 3

Phase 3 study for people with Autosomal Dominant Polycystic Kidney Disease
Where
No Australian site on this record is listed as recruiting right now, even though the trial itself is open. Check with the site or the official record before travelling.
- Renal Research, Gosford (NSW) — Active not recruiting
- Royal Prince Alfred Hospital, Sydney (NSW) — Active not recruiting
- Royal North Shore Hospital, Sydney (NSW) — Active not recruiting
- Westmead Hospital - Western Sydney Local Health District, Sydney (NSW) — Active not recruiting
- Bundaberg Hospital, Bundaberg (QLD) — Active not recruiting
- Townsville University Hospital, Douglas (QLD) — Active not recruiting
- Royal Brisbane and Women's Hospital, Herston (QLD) — Active not recruiting
- Princess Alexandra Hospital, Woolloongabba (QLD) — Active not recruiting
- Royal Adelaide Hospital, Adelaide (SA) — Active not recruiting
- Royal Melbourne Hospital, Melbourne (VIC) — Active not recruiting
- Austin Health, Melbourne (VIC) — Active not recruiting
- Monash Medical Centre, Melbourne (VIC) — Active not recruiting
- Sir Charles Gairdner Hospital, Perth (WA) — Active not recruiting
Who can join Age 18 Years to 70 Years. Sex Anyone, regardless of sex. Healthy volunteers Not accepted.

Sponsor The University of Queensland

Timeline

Started 29 November 2022 Today 16 October 2026 Estimated completion 1 December 2030
NCT04939935 · Checked 11 October 2026

Trial details Summary for your GP Official record and contacts
Recruiting Phase 1

Phase 1 study for people with Autosomal Dominant Polycystic Kidney Disease
Where
- South Coast Renal, Brockway House, Level 1, Suite 8, 82-86 Queen Street,, Southport (QLD) — Recruiting
- Concord Repatriation General Hospital, Concord (NSW) — Recruiting
- Liverpool Hospital, Clinic G-Reception 133, Level 1, Clinical Building, Burnside Drive, Liverpool (NSW) — Recruiting
- Scientia Clinical Research, Randwick (NSW) — Recruiting
- Sydney Adventist Hospital, Wahroonga (NSW) — Recruiting
- Westmead Hospital, Clinical Research Unit, Level 6, B Wing/Building, Hawkesbury Road, Westmead (NSW) — Recruiting
- Mater Hospital Brisbane, South Brisbane (QLD) — Recruiting
- St Vincent's Hospital Melbourne, Fitzroy (VIC) — Recruiting
- Sunshine Hospital, Western Centre for Health Research and Education, Level 3, 176-190 Furlong Road, Saint Albans (VIC) — Recruiting
- Linear Clinical Research, Joondalup (WA) — Recruiting
Who can join Age 18 Years to 65 Years. Sex Anyone, regardless of sex. Healthy volunteers Accepted.

Sponsor PYC Therapeutics

Timeline

Started 7 April 2025 Today 16 October 2026 Estimated completion 1 November 2028
NCT06714006 · Checked 11 October 2026

Trial details Summary for your GP Official record and contacts
Recruiting Phase 2

Phase 2 study for people with Autosomal Dominant Polycystic Kidney Disease
Where
- Westmead Hospital, Westmead (NSW) — Recruiting
- Royal Brisbane and Women's Hospital, Brisbane (QLD) — Recruiting
- Royal Adelaide Hospital, Adelaide (SA) — Recruiting
- Fiona Stanley Hospital, Murdoch (WA) — Recruiting
Who can join Age 18 Years to 55 Years. Sex Anyone, regardless of sex. Healthy volunteers Not accepted.

Sponsor Calico Life Sciences LLC

Timeline

Started 9 June 2025 Today 16 October 2026 Estimated completion 1 August 2029
NCT06902558 · Checked 13 October 2026

Trial details Summary for your GP Official record and contacts
Recruiting Phase 1

Phase 1 study for people with Autosomal Dominant Polycystic Kidney Disease
Where
- CMAX Clinical Research, Adelaide (SA) — Recruiting
Who can join Age 18 Years to 65 Years. Sex Anyone, regardless of sex. Healthy volunteers Accepted.

Sponsor Gilva Therapeutics Inc.

Timeline

Started 23 June 2026 Today 16 October 2026 Estimated completion 31 March 2027
NCT07788014 · Checked 11 October 2026

Trial details Summary for your GP Official record and contacts

Trials overseas

38 trials for this disease are open to new participants outside Australia, as ClinicalTrials.gov listed them on 11 October 2026. Voxsanity does not publish a page for any of them; the searches below reach them at the registry.

These overseas counts are likely too high. They come from the registry’s own search, which expands a condition name to related conditions, so some of the trials counted are for a different disease in the same family.

Search ClinicalTrials.gov Search the WHO registry portal Joining a trial overseas

Trials not shown here

Some Australian trials are registered only on the Australian New Zealand Clinical Trials Registry and are not shown here. Search them at Australian Clinical Trials.

Key facts

Inheritance Autosomal dominant

Genes PKD1, PKD2, ALG9, NEK8, BICC1, IFT140, GANAB, DNAJB11, ALG5

Prevalence 1-5 / 10 000 (Point prevalence, Europe, Validated)

Age of onset Adolescent; Adult; Childhood

Orphadata Science: Free access data from Orphanet. © INSERM 1999. Available on https://www.orphadata.com. Used under CC BY 4.0. Source: Orphanet / Orphadata (orphadata.com).

About Autosomal Dominant Polycystic Kidney Disease

The text below is reproduced exactly as its source published it. It has not been edited, shortened or rewritten.

Polycystic kidney disease is a disorder that affects the kidneys and other organs. Clusters of fluid-filled sacs, called cysts, develop in the kidneys and interfere with their ability to filter waste products from the blood. The growth of cysts causes the kidneys to become enlarged and can lead to kidney failure. Cysts may also develop in other organs, particularly the liver. Frequent complications of polycystic kidney disease include dangerously high blood pressure (hypertension), pain in the back or sides, blood in the urine (hematuria), recurrent urinary tract infections, kidney stones, and heart valve abnormalities. Additionally, people with polycystic kidney disease have an increased risk of an abnormal bulging (an aneurysm) in a large blood vessel called the aorta or in blood vessels at the base of the brain. Aneurysms can be life-threatening if they tear or rupture. The two major forms of polycystic kidney disease are distinguished by the usual age of onset and the pattern in which it is passed through families. The autosomal dominant form (sometimes called ADPKD) has signs and symptoms that typically begin in adulthood, although cysts in the kidney are often present from birth or childhood. Autosomal dominant polycystic kidney disease can be further divided into type 1 and type 2, depending on the genetic cause. The autosomal recessive form of polycystic kidney disease (sometimes called ARPKD) is much rarer and is often lethal early in life. The signs and symptoms of this condition are usually apparent at birth or in early infancy.

US source; availability in Australia may differ.

Source: MedlinePlus Genetics (medlineplus.gov), public domain (U.S. National Library of Medicine). Read the full source.

Sources and dates

ClinicalTrials.gov – trial records, statuses and site lists
MedlinePlus – the About text above, reproduced exactly
Orphanet / Orphadata – prevalence, age of onset, inheritance, genes and alternative names, used under CC BY 4.0
ClinicalTrials.gov processing date: 6 October 2026.
This page last checked by Voxsanity: 13 October 2026.

Voxsanity reformats data from public registries into this layout. It does not edit, interpret or add to what the registry published.

Not medical advice.

Individual trial records are refreshed on a rolling basis rather than all at once, so a record may be up to several weeks old. Each trial page and trial card shows the date its own record was last synced. Where a record has lagged, its status, sites and enrolment can differ from the current registry state in either direction, so check the registry link on the trial page before acting on them.

Orphanet citation

Orphadata Science: Free access data from Orphanet. © INSERM 1999. Available on https://www.orphadata.com. Used under CC BY 4.0. Source: Orphanet / Orphadata (orphadata.com). Accessed 20 September 2026.

ORPHA:730

Autosomal Dominant Polycystic Kidney Disease is one of the rare diseases tracked on the Voxsanity rare disease hub, where you can compare it with every other rare condition we follow and filter trials by country.

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