NCT00053352

Who might be able to join this trial:

• You have a germ cell tumor located outside the brain that contains at least one of these tumor types: yolk sac tumor, embryonal carcinoma, or choriocarcinoma (mixed tumors that also contain mature or immature teratoma may still qualify).
• For lower-risk patients (note: this group is no longer enrolling as of January 2010): you have a Stage I tumor of the ovary or testicle, and full surgical and imaging tests have been done to confirm it has not spread further.
• For intermediate-risk patients, you have one of the following: a Stage II, III, or IV malignant testicular germ cell tumor; a Stage II or III malignant ovarian germ cell tumor; a Stage I or II malignant germ cell tumor that started outside the ovaries or testicles; or your tumor has come back after previously being monitored as a lower-risk case.
• You have had specific blood tumor marker tests done (alpha-fetoprotein and beta-hCG), and if more than 5 days have passed since the original tests, they have been repeated before joining the trial.
• You are enrolling within 6 weeks of your original surgery to remove or diagnose the tumor.
• Your kidneys are working well enough, based on age- and gender-specific blood test results (confirm with trial site for the exact values that apply to you).
• You have not had any chemotherapy before joining this trial.
• You have not had any radiation therapy before joining this trial.

Who may not be able to join:

• You have a Stage IV ovarian germ cell tumor or a Stage III–IV germ cell tumor that started outside the ovaries or testicles.
• Your germ cell tumor is located in the brain.
• Your tumor is purely mature teratoma, immature teratoma, dysgerminoma, or seminoma, with no other malignant germ cell component.
• Your tumor contains non-germ cell cancer elements, such as primitive neuroectodermal tumor or rhabdomyosarcoma.
• Your kidney function test results are below the required levels for your age and gender (confirm with trial site).

Important: Always verify eligibility with the trial site directly before applying.