NCT00053365

Who might be able to join this trial:

• You have been diagnosed with ovarian cancer or primary peritoneal cancer (a related cancer starting in the lining of the abdomen), confirmed by a laboratory test on a tissue sample
• Your cancer has come back or has not gone away completely
• You have at least one tumor that can be measured on a scan (at least 20mm using standard imaging, or at least 10mm using a spiral CT scan)
• You have previously received one chemotherapy treatment that included a platinum-based drug (such as carboplatin or cisplatin) for your original diagnosis
• If you have not previously received paclitaxel (a common chemotherapy drug), you may have had a second treatment course containing it
• Your cancer responded to platinum-based treatment, but came back between 6 and 12 months after finishing it, with no signs of the cancer growing during that gap
• You are in reasonably good general health, able to carry out daily activities (confirm with trial site for exact fitness level required based on your treatment history)
• Your blood cell counts are at healthy enough levels (your trial team will check this with blood tests)
• Your liver and kidney function are within acceptable ranges (your trial team will check this)
• You have tested negative for pregnancy
• If you are able to become pregnant, you are willing to use effective birth control during the trial

Who may not be able to join:

• You have had a heart failure condition that required medication
• You have had uncontrolled high blood pressure in the past 6 months
• You are currently pregnant or breastfeeding
• You have had another serious (invasive) cancer in the past 5 years, not including certain common skin cancers
• You have a history of eye conditions affecting the retina or the central part of your eye (called macular degeneration)
• You have nerve damage (affecting feeling or movement) beyond a mild level
• You currently have an active infection being treated with antibiotics
• You have had a bone marrow or stem cell transplant in the past
• You have previously been treated with a drug called irofulven
• You have received more than one additional chemotherapy treatment since your cancer came back
• You have previously had radiation therapy covering more than a quarter of your bone marrow areas
• You have had more than one non-chemotherapy (targeted or biological) treatment for your cancer since it came back
• You have any other health condition that the trial doctors feel would make it unsafe for you to participate (confirm with trial site)
• You have had recent treatments that have not been given enough time to recover from (generally at least 3 weeks are needed since most prior treatments)

Important: Always verify eligibility with the trial site directly before applying.