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This trial is complete. It is no longer accepting participants. Results may be available on ClinicalTrials.gov.

NCT00072410

NCT00072410
Completed Phase 1

Who may be able to join

Who might be able to join this trial:

  • You have been diagnosed with a specific type of ovarian cancer (non-mucinous ovarian adenocarcinoma), confirmed by a lab test on tissue.
  • Your ovarian cancer (Stage 3) has come back or has not fully gone away after treatment with platinum- and taxane-based chemotherapy, and the cancer is inside the abdomen.
  • The remaining cancer in your body is smaller than 2 cm (about the size of a small grape).
  • Your recent blood tests and other lab results (taken within the last 2 weeks) show that your blood counts, liver, kidney, lung, and heart function are all within acceptable ranges (confirm specific values with trial site).
  • You are generally able to carry out normal daily activities, as measured by a standard health performance scale (Karnofsky score of 70 or above).
  • You are willing and able to sign a written consent form agreeing to take part in the trial.
  • You are able to have a small tube (catheter) placed inside your abdomen during surgery as part of the treatment.

Who may not be able to join:

  • Your cancer has spread to organs outside the abdomen (Stage IV disease).
  • You have cancer that has spread outside the abdomen and is causing symptoms.
  • The cancer has spread to your brain or spinal cord.
  • You have significant heart disease that limits your daily activities (confirm with trial site).
  • A recent heart test (ECG) shows a serious irregular heartbeat or signs of a previous heart attack.
  • You have other serious health conditions, such as an active serious infection requiring antibiotics, or a bleeding disorder that may make surgery or the treatment unsafe.
  • You have a long-term inflammatory bowel condition (such as Crohn's disease or ulcerative colitis).
  • You have received chemotherapy, biological therapy, or immunotherapy within the last 4 weeks before joining the trial.
  • You are currently pregnant or breastfeeding.
  • You have previously received a certain type of antibody treatment (murine monoclonal antibody), or a blood test shows your immune system may react against the treatment used in this trial (confirm with trial site).

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

Phase 1: approximately ~10% of drugs entering this phase reach regulatory approval, based on published industry-wide historical data. This is not specific to this trial.

Trial details

Status
Completed
Phase
Phase 1
Sponsor
Ludwig Institute for Cancer Research
Registry
clinicaltrials_gov
Start date
1 November 2003
Est. completion
1 May 2005

Where this trial is recruiting

🇺🇸 United States

Primary endpoints

Number of Patients With Dose-limiting Toxicities (DLTs)

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 30 June 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

View original record on ClinicalTrials.gov